Dual-Responsive Alginate Hydrogels for Controlled Release of Therapeutics.

IF 4.6 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules Pub Date : 2019-05-31 DOI:10.3390/molecules24112089

Xuexia Lin, Qiaoqiao Ma, Jianlong Su, Cui Wang, Ranjith Kumar Kankala, Mingrong Zeng, Honggui Lin, Shu-Feng Zhou

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引用次数: 12

Abstract

In this work, with the drug oxytetracycline (OTC) released, cell cytotoxicity and antimicrobial studies of dual-responsive sodium alginate and N-Isopropylacrylamide hydrogels (SA/pNIPAAm) with enclosed OTC were investigated. The molecular OTC release was explored with different acid-base conditions and temperature conditions. In order to characterize cell cytotoxicity and antimicrobial efficacy, time-dependent OTC release analysis of different acid-base conditions was performed in SA/pNIPAAm hydrogels. OTC@SA/pNIPAAm hydrogels showed excellent time-dependent antimicrobial efficacy, in which the IC50 values were 50.11 μg mL^-1, 34.27 μg mL^-1, and 22.39 μg mL^-1 among three consecutive days, respectively. Meanwhile, the human cells showed excellent viability at the IC50 dosage of OTC@SA/pNIPAAm (50.11 μg mL^-1). OTC@SA/pNIPAAm performed in this study indicated that SA/pNIPAAm may serve as drug carriers for sustainable release at a specific concentration and for being employed as substrates for decreasing drug toxicity. Besides, pH-responsive and thermos-responsive SA/pNIPAAm may lead to the better selectivity of drug release in the ideal location or site. Finally, the results demonstrate that the designed, dual-responsive, biocompatible OTC@SA/pNIPAAm hydrogels showed excellent antimicrobial efficacy and may potentially be found to have enormous applicability in the field of pharmaceutics.

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用于治疗药物控释的双反应藻酸盐水凝胶。

随着土霉素(OTC)的释放，研究了封闭OTC的海藻酸钠/ n -异丙基丙烯酰胺双反应水凝胶(SA/pNIPAAm)的细胞毒性和抗菌性能。考察了不同酸碱条件和温度条件下OTC的分子释放情况。为了表征SA/pNIPAAm水凝胶的细胞毒性和抗菌功效，对不同酸碱条件下的OTC释放进行了时间依赖性分析。OTC@SA/pNIPAAm水凝胶具有良好的时间依赖性抗菌效果，其连续3 d的IC50值分别为50.11、34.27和22.39 μ mL-1。同时，在IC50剂量OTC@SA/pNIPAAm (50.11 μ mL-1)下，人细胞表现出良好的活力。OTC@SA/pNIPAAm表明，SA/pNIPAAm可以作为药物载体，在特定浓度下持续释放，并作为降低药物毒性的底物。此外，ph响应性和热响应性的SA/pNIPAAm可能导致药物在理想位置或部位释放的选择性更好。最后，结果表明，设计的双响应、生物相容性OTC@SA/pNIPAAm水凝胶具有良好的抗菌功效，可能在制药领域具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.