Symptoms-modifying effects of electromotive administration of glucosamine sulphate among patients with knee osteoarthritis.

Pub Date : 2018-06-01 Epub Date: 2018-04-27 DOI:10.1142/S1013702518500075

Ayodele Teslim Onigbinde, Adegbenga Rotimi Owolabi, Kamil Lasisi, Sarah Oghenekewe Isaac, Adeoye Folorunsho Ibikunle

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引用次数: 6

Abstract

Background: Most trials on symptom-modifying effects of glucosamine are limited to administration through oral route with dearth of empirical data on the use of electromotive force.

Objective: The study determined the effects of glucosamine sulphate (GS) iontophoresis (IoT) on radiographic parameters of patients with knee osteoarthritis (OA).

Methods: Fifty-three patients were randomly assigned to three groups. About 1 g each of GS was administered using IoT and cross-friction massage (CFM) for participants in groups 1 (IoT) and 2 (CFM), respectively. Group 3 ((Combined therapy) CoT) received 1 g of GS using both IoT and CFM. Interventions were twice a week for 12 weeks. Analysis of variance (ANOVA) was used to analyze the data ( $p < 0.05$ ).

Results: After 12 weeks, the medial joint space width (JSW) of the CFM group was significantly higher than that of IoT and CoT groups ( $p = 0.005$ and $p = 0.004$ ). Lateral JSW of IoT group was significantly higher than both CFM ( $p = 0.001$ ) and CoT groups ( $p = 0.01$ ). There were significant decreases in pain intensities; increase in knee flexion and physical functions across the groups ( $F = 9.33, p = 0.01; F = 3.23, p = 0.01$ ; $H = 4.97, p = 0.01$ , respectively).

Conclusion: It was concluded that there were significant decreases in the degenerative changes at the knee joint.

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电动给药硫酸氨基葡萄糖对膝关节骨关节炎患者症状的改善作用。

背景:大多数关于葡萄糖胺改善症状作用的试验仅限于口服给药，缺乏电动势使用的经验数据。目的:研究硫酸氨基葡萄糖(GS)离子透入(IoT)对膝关节骨性关节炎(OA)患者影像学参数的影响。方法:53例患者随机分为3组。第1组(IoT)和第2组(CFM)分别采用物联网和交叉摩擦按摩(CFM)方式给予GS各约1g。第三组((联合治疗)CoT)采用IoT和CFM同时给予1g GS。干预每周两次，持续12周。采用方差分析(ANOVA)对数据进行分析(p < 0.05)。结果:12周后，CFM组内侧关节间隙宽度(JSW)显著高于IoT组和CoT组(p = 0.005和p = 0.004)。IoT组侧侧JSW显著高于CFM组(p = 0.001)和CoT组(p = 0.01)。疼痛强度显著降低;各组患者膝关节屈曲度和身体功能均增加(F = 9.33, p = 0.01;F = 3.23, p = 0.01;H = 4.97, p = 0.01)。结论:膝关节退行性改变明显减少。

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