The Synergistic Role of Diet and Exercise in the Prevention, Pathogenesis, and Management of Ulcerative Colitis: An Underlying Metabolic Mechanism.

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2019-03-19 eCollection Date: 2019-01-01 DOI:10.1177/1178638819834526

Jonah Stavsky, Radhashree Maitra

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Abstract

Ulcerative colitis (UC) is a biologically complex condition characterized by chronic, relapsing inflammation of the gastrointestinal tract. The relative incidence of this debilitating condition is increasing and sociologically damaging outcomes are a continued reality. Several etiological theories for UC are currently under investigation, spanning between genetic and environmental determinants. From an environmental perspective, previous literature reviews have demonstrated the independent effectiveness of specific diet and exercise patterns in modifying UC immuno-pathophysiology. This article explores the synergistic role of diet and aerobic exercise in the prevention, pathogenesis, and management of UC in the context of recent immunological research. Through a unifying mechanism-that is, microbial influence of colonic inflammation and immuno-pathophysiology-the simultaneous reduction of pro-inflammatory dietary sulfurous amino acid intake (ie methionine, cysteine, homocysteine, and taurine) and the upregulation of aerobic exercise frequency (which spurs the colonization of anti-inflammatory butyrate, acetate, and propionate producing microbial taxa) demonstrate the clinical efficacy of incorporating both diet and exercise modifications for UC prevention and management through pathogenic alterations.

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饮食和运动在溃疡性结肠炎的预防、发病机制和治疗中的协同作用：潜在的代谢机制

溃疡性结肠炎（UC）是一种生物复杂性疾病，以慢性、复发性胃肠道炎症为特征。这种使人衰弱的疾病的相对发病率在不断上升，对社会造成破坏的结果也是持续存在的现实。目前正在研究 UC 的几种病因理论，其中既有遗传因素，也有环境因素。从环境角度来看，以往的文献综述表明，特定的饮食和运动模式在改变 UC 免疫病理生理学方面具有独立的有效性。本文结合最新的免疫学研究，探讨了饮食和有氧运动在 UC 的预防、发病机制和管理中的协同作用。通过一种统一的机制，即微生物对结肠炎症和免疫病理生理学的影响，同时减少促炎症饮食含硫氨基酸（即蛋氨酸、半胱氨酸、同型半胱氨酸和牛磺酸）的摄入量，并增加有氧运动的摄入量、和牛磺酸），并增加有氧运动频率（促进产生抗炎作用的丁酸盐、醋酸盐和丙酸盐微生物类群的定植），这证明了通过改变病原体来预防和控制 UC 的饮食和运动调整具有临床疗效。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.