Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population.

Q2 Medicine
BMC Clinical Pathology Pub Date : 2019-03-18 eCollection Date: 2019-01-01 DOI:10.1186/s12907-019-0086-7
Bertille Elodie Edinga-Melenge, Adrienne Tchapmi Yakam, Jobert Richie Nansseu, Catherine Bilong, Suzanne Belinga, Eric Minkala, Prisca Armel Noudjeu, Michel Ondhoua, Samuel Walter Kokola, Vicky Joceline Ama Moor, Gloria Ashuntantang
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引用次数: 12

Abstract

Background: Serum cystatin C (SCysC) and serum creatinine (SCr) are two biomarkers used in common practice to estimate the glomerular filtration rate (GFR). For SCysC and SCr to be used in a given population, normal values need to be determined to better assess patients. This study aimed to determine SCysC and SCr reference intervals (RIs) in a Cameroonian adult population and factors susceptible of influencing them.

Methods: We carried-out a cross-sectional study from November 2016 to May 2017 in Yaoundé, Cameroon. Participants were Cameroonians aged 18 years and above, residing inside the country and found in good health at study inclusion. SCysC and SCr were determined by particle-enhanced turbidimetric immunoassay standardized against the ERM-DA471/IFCC reference material and by the IDMS reference modified Jaffe kinetic method, respectively. RIs were determined using the 2.5th and 97.5th percentiles and their respective 90% confidence intervals (CIs). The quantile regression served to identify potential factors likely influencing SCysC and SCr values.

Results: We included 381 subjects comprising 49.1% females.. RIs for SCysC varied between 0.57 (90%CI: 0.50-0.60) and 1.03 mg/L (90%CI: 1.00-1.10) for females, and from 0.70 (90%CI: 0.60-0.70) to 1.10 mg/L (90%CI: 1.10-1.20) for males. Concerning SCr, its RIs ranged from 0.58 (90%CI: 0.54-0.61) to 1.08 mg/dL (90%CI: 1.02-1.21) for females, and from 0.74 (90%CI: 0.70-0.80) to 1.36 mg/dL (90%CI: 1.30-1.45) for males. Men had significantly higher SCysC and SCr values than women (p <  0.001). Likewise, subjects aged 50 years and above had higher SCysC values in comparison to younger age groups (p <  0.001), which was not the case for SCr values (p = 0.491). Moreover, there was a positive and significant correlation between SCysC and SCr in women (ρ = 0.55, p < 0.001), in men (ρ = 0.39, p < 0.001) and globally (ρ = 0.58; p < 0.001). Furthermore, the sex influenced both biomarkers' values across all quantile regression models while age and body surface area (BSA) influenced them inconsistently.

Conclusion: This study has determined serum cystatin C and serum creatinine reference intervals in an adult Cameroonian population, whose interpretations might take into account the patient's sex and to a certain extent, his/her age and/or BSA.

Abstract Image

Abstract Image

撒哈拉以南非洲成年人血清胱抑素C和血清肌酐的参考区间。
背景:血清胱抑素C (SCysC)和血清肌酐(SCr)是评估肾小球滤过率(GFR)的两种常用生物标志物。对于在特定人群中使用SCysC和SCr,需要确定正常值以更好地评估患者。本研究旨在确定喀麦隆成年人群的SCysC和SCr参考区间(RIs)以及影响它们的易感因素。方法:我们于2016年11月至2017年5月在喀麦隆雅温达尔开展了一项横断面研究。参与者是18岁及以上的喀麦隆人,居住在国内,在纳入研究时健康状况良好。SCysC和SCr分别采用ERM-DA471/IFCC标准物质标准化的颗粒增强浊度免疫分析法和IDMS标准改进的Jaffe动力学法测定。RIs采用2.5和97.5百分位及其各自的90%置信区间(ci)确定。分位数回归用于识别可能影响SCysC和SCr值的潜在因素。结果:纳入381例受试者,其中女性49.1%。女性SCysC的RIs在0.57 (90%CI: 0.50-0.60)至1.03 mg/L (90%CI: 1.00-1.10)之间变化,男性SCysC的RIs在0.70 (90%CI: 0.60-0.70)至1.10 mg/L (90%CI: 1.10-1.20)之间变化。在SCr方面,女性的RIs范围为0.58 (90%CI: 0.54 ~ 0.61) ~ 1.08 mg/dL (90%CI: 1.02 ~ 1.21),男性的RIs范围为0.74 (90%CI: 0.70 ~ 0.80) ~ 1.36 mg/dL (90%CI: 1.30 ~ 1.45)。男性SCysC和SCr值明显高于女性(p p = 0.491)。结论:本研究确定了喀麦隆成年人群的血清胱抑素C和血清肌酐参考区间,其解释可能考虑了患者的性别,并在一定程度上考虑了患者的年龄和/或BSA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Clinical Pathology
BMC Clinical Pathology Medicine-Pathology and Forensic Medicine
CiteScore
3.30
自引率
0.00%
发文量
0
期刊介绍: BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.
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