The role of Lactobacillus reuteri DSM 17938 for the absorption of iron preparations in children with iron deficiency anemia.

Korean Journal of Pediatrics Pub Date : 2019-05-01 Epub Date: 2019-01-25 DOI:10.3345/kjp.2018.07024
Jeanette Manoppo, Hilda Tasiringan, Audrey Wahani, Adrian Umboh, Max Mantik
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引用次数: 2

Abstract

Purpose: To determine whether Lactobacillus reuteri DSM 17938 plays a role in absorption of iron preparations given to children with iron deficiency anemia (IDA).

Methods: We performed a quasi-experimental study involving pre- and postintervention tests using a control group in North Sulawesi province, Indonesia, between July and September 2017. We conducted a single-blind controlled trial that included primary school children who were diagnosed with IDA based on reticulocyte hemoglobin equivalent (Ret-He) levels <27.8 pg/L.

Results: A total of 66 children were randomized into 2 groups. Thirty-four children received iron preparations with the addition of L. reuteri DSM 17938 (group 1), whereas the other 32 received iron preparations alone (group 2). The baseline Ret-He levels before intervention were similar in both groups. After 14 days of intervention, mean Ret-He level in group 1 changed from 24.43±1.64 to 28.21±1.72 pg/ L (P=0.000). Mean Ret-He level in group 2 changed from 24.31±1.42 to 27.03±2.14 pg/L (P=0.000). Statistical analysis showed a significant increase in Ret-He levels in both groups; Ret-He levels were significantly higher in the experimental group than in the control group (P<0.05).

Conclusion: Children with IDA receiving iron preparations with L. reuteri DSM 17938 for 14 days show higher Ret-He levels than those receiving iron preparations alone.

Abstract Image

罗伊氏乳杆菌DSM 17938对缺铁性贫血儿童铁制剂吸收的作用。
目的:探讨罗伊氏乳杆菌DSM 17938在缺铁性贫血(IDA)患儿铁制剂吸收中的作用。方法:我们于2017年7月至9月在印度尼西亚北苏拉威西省进行了一项准实验研究,包括干预前和干预后测试,使用对照组。我们进行了一项单盲对照试验,纳入了根据网织红细胞血红蛋白当量(Ret-He)水平诊断为IDA的小学生。结果:共有66名儿童随机分为两组。34名儿童接受了添加罗伊氏乳杆菌DSM 17938的铁制剂(组1),而其他32名儿童单独接受铁制剂(组2)。两组干预前的基线Ret-He水平相似。干预14 d后,组1平均Ret-He水平由24.43±1.64 pg/ L降至28.21±1.72 pg/ L (P=0.000)。2组平均Ret-He水平由24.31±1.42 pg/L降至27.03±2.14 pg/L (P=0.000)。统计分析显示,两组患者的Ret-He水平均显著升高;结论:IDA患儿服用含罗伊氏乳杆菌DSM 17938的铁制剂14 d后,其Ret-He水平明显高于单纯服用铁制剂组。
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来源期刊
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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