A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies.

IF 3.1 Q2 ONCOLOGY
Oncology Reviews Pub Date : 2019-04-16 eCollection Date: 2019-01-14 DOI:10.4081/oncol.2019.409
Abdul Aziz Mohamed Yusoff, Wan Salihah Wan Abdullah, Siti Zulaikha Nashwa Mohd Khair, Siti Muslihah Abd Radzak
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引用次数: 32

Abstract

Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA4977) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA4977 formation and a detailed summary about mDNA4977 reported in various types of cancers. The current knowledges of mDNA4977 as a prognostic and predictive marker are also discussed.

Abstract Image

线粒体DNA 4977-bp缺失在癌症研究中的全面概述。
线粒体是产生能量必不可少的细胞机器。线粒体的生物发生是一个高度复杂的过程,它依赖于细胞核和线粒体基因组的协调。线粒体DNA (mtDNA)突变和缺失被怀疑与致癌有关。在各种人类癌症中被描述最多的mtDNA缺失被称为4977-bp共同缺失(mDNA4977),它已经被探索了20年。尽管如此,其在癌变中的意义仍然未知,其预测和预后影响仍然存在争议。本文综述了mDNA4977形成的一些细胞和分子机制,并详细总结了mDNA4977在各种类型癌症中的报道。本文还讨论了目前关于mDNA4977作为预后和预测标志物的知识。
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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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