Polymeric Mixed Micelles: Improving the Anticancer Efficacy of Single-Copolymer Micelles.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2019-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2018020481

Arehalli S Manjappa, Popat S Kumbhar, John I Disouza, Vandana B Patravale

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引用次数: 28

Abstract

Mixed micelles self-assembled from two or more dissimilar block copolymers provide a direct and convenient approach to improved drug delivery. The present review is focused on mixed micelles (prepared from block copolymers only) for various drug delivery applications along with their merits over single-copolymer micelles. Presented are the physicochemical properties of mixed and single-copolymer micelles, various stimuli-responsive mixed micelles for the treatment of cancer, interesting combinations of multifunctional mixed micelles along with their in vitro and in vivo performance, and the potential of mixed micelles as a gene delivery system. Finally, the performance of mixed micelles in preclinical and clinical testing is explained. In addition, the interaction of mixed micelles with cancer cells and the biosafety of mixed micelles are summarized. The in vitro and in vivo performance presented here clearly reveals that the mixed-micelle approach has a wider scope than that of the single-copolymer micelle approach and directs researchers to focus on this approach to delivery of drugs/gene/biologics for various applications.

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聚合物混合胶束:提高单共聚胶束的抗癌效果。

由两种或多种不同嵌段共聚物自组装的混合胶束为改善药物传递提供了直接和方便的方法。目前的综述集中在混合胶束(仅由嵌段共聚物制备)用于各种药物输送应用以及它们比单共聚物胶束的优点。介绍了混合胶束和单共聚物胶束的物理化学性质，用于治疗癌症的各种刺激响应混合胶束，多功能混合胶束的有趣组合及其体外和体内性能，以及混合胶束作为基因传递系统的潜力。最后，阐述了混合胶束在临床前和临床试验中的性能。此外，还综述了混合胶束与癌细胞的相互作用以及混合胶束的生物安全性。这里展示的体外和体内性能清楚地揭示了混合胶束方法比单共聚物胶束方法具有更广泛的应用范围，并指导研究人员将重点放在这种方法上，以用于各种应用的药物/基因/生物制剂的递送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.