Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I2 under air at room temperature†

IF 9.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2022-01-01 DOI:10.1039/d2gc02058k

Yuling Lu , Chunmei Chen , Hucheng Zhu , Zengwei Luo , Yonghui Zhang

引用次数: 2

Abstract

Without using any additives, a green and efficient procedure for the preparation of valuable di-iodinated succinimide derivatives has been achieved through the iodine radical-initiated cascade cyclization of 1,6-enynes. This protocol could be conducted in MeCN in open air at room temperature with good to excellent yields. Notably, this method is highly atom- and time-economical, safe to operate, easy to scale up, and has excellent functional group compatibility. Moreover, this is the first example of di-iodinolysis cyclization using iodine radical cascade reaction.

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1,6-炔和I2在室温下高效快速合成二碘化琥珀酰亚胺衍生物

在不使用任何添加剂的情况下，通过碘自由基引发1,6-烯的级联环化，实现了一种绿色高效的制备有价值的二碘琥珀酰亚胺衍生物的方法。该工艺可在室温下露天进行，产率良好。值得注意的是，该方法具有高度的原子经济性和时间经济性，操作安全，易于扩展，并且具有良好的官能团相容性。此外，这是使用碘自由基级联反应的二碘解环化的第一个例子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.