Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics".

Q3 Medicine
Vishal Chavda, Snehal Patel
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引用次数: 0

Abstract

Lyme's Disease (LD) is a severe, rapidly growing, broad spectrum chronic infection caused by the bacterium 'Borrelia (B.) burgdorferi', which can be easily transmitted through the bite of certain species of ticks. The prevalence of LD is swiftly mounting in the present scenario in many countries from species to species. Although Lyme's infection is now detectable via serologic examination of early and late Lyme neuroborreliosis (LNB), the management of persistent symptoms is still fraught with quora of doubt and debate. LD is a multisystem spirochete which results after the dissemination of B. burgdorferi from a dermal inoculation site after a tick bite. Lyme's infection can easily get transmitted to the central nervous system and develop various neurological symptoms due to inflammation and an autoimmune response from body may lead to life-threatening "Lyme Borreliosis". The neurological symptoms are well mixed in presentation, late and confusing to get differentiated easily from other diseases. The use of antibiotics in post Lyme infection with neurological complications is still a topic of debate. Babesiosisstates, and human ehrlichiosis' the two other diseases, are associated with the same ticks that spread the LD. However, the prevalence of diagnosed human cases is usually much lower than that of actual cases of LD due to misdiagnosis, late diagnosis or undiagnosis at y such lateral neuroinfection stage after the tick bite. The current review focuses on the molecular neuropathology and current advancements in LD. There are very few patents or discoveries made on borrelia infection, drawing attention towards more focused and targeted research for the cure.

莱姆病神经螺旋体-神秘的陷阱:“神经病理学和当前的治疗”。
莱姆病(LD)是一种严重的、迅速发展的广谱慢性感染,由伯氏疏螺旋体(B.)伯氏疏螺旋体引起,它很容易通过某些种类的蜱虫叮咬传播。在目前的情况下,在许多国家,从一个物种到另一个物种,致病菌的发病率正在迅速上升。虽然莱姆病感染现在可以通过早期和晚期莱姆病神经螺旋体病(LNB)的血清学检查检测到,但持续症状的管理仍然充满了疑问和争论。LD是一种多系统螺旋体,由蜱叮咬后皮肤接种部位传播伯氏疏螺旋体引起。莱姆病感染很容易传播到中枢神经系统,并因炎症和身体自身免疫反应而出现各种神经系统症状,可能导致危及生命的“莱姆病”。神经系统症状表现混杂,较晚,易混淆,易与其他疾病鉴别。莱姆病后感染伴神经系统并发症的抗生素使用仍是一个有争议的话题。巴贝斯虫病和人类埃利希体病这两种疾病与传播LD的同一种蜱有关。然而,由于在蜱叮咬后的这种侧神经感染阶段误诊、诊断晚或未诊断,诊断出的人类LD病例的患病率通常远低于实际病例。目前的综述主要集中在分子神经病理学和LD的最新进展。关于伯氏疏螺旋体感染的专利或发现很少,引起人们对更集中和有针对性的治疗研究的关注。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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