Individuals with Hyperthyroidism are More Susceptible to having a Serious Serotonin Syndrome Following MDMA (Ecstasy) Administration in Rats.

Annals of forensic research and analysis Pub Date : 2018-01-01 Epub Date: 2018-11-12

Ibrahim M Shokry, Kayla DeSuza, John J Callanan, Giselle Shim, Zhiyuan Ma, Rui Tao

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Abstract

In a recreational use of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"), some but not all users are stricken with a serious serotonin (5-hydroxytryptamine; 5-HT) syndrome. This raises a question as to whether there exist subpopulations that are more susceptible to MDMA intoxication. The hypothesis was tested with hyperthyroid versus euthyroid rats by measuring changes in body-core temperature (T _cor) and 5-HT in the hypothalamus. In the euthyroid rats, injection of MDMA at a recreationally relevant dose had no serious effect on T _cor. In contrast, the same dose was sufficient to evoke life-threatening hyperthermia in hyperthyroid rats. Neurochemical studies revealed that there was greater 5-HT efflux in the hyperthyroid than the euthyroid rats. These effects were blocked by pretreatment with M100907, a 5-HT_2A receptor antagonist. In summary, our data support the hypothesis that individuals with hyperthyroidism are more susceptible to having a serious serotonin syndrome following MDMA administration.

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患有甲状腺机能亢进的个体在服用MDMA(摇头丸)后更容易出现严重的血清素综合征。

在娱乐性使用3,4-亚甲基二氧甲基苯丙胺(MDMA，“摇头丸”)时，一些但不是所有的使用者都会受到严重的血清素(5-羟色胺;5)综合症。这就提出了一个问题，即是否存在对MDMA中毒更敏感的亚群。通过测量体核温度(T cor)和下丘脑5-羟色胺的变化，对甲状腺功能亢进和甲状腺功能正常的大鼠进行了验证。在甲状腺功能正常的大鼠中，注射与娱乐相关剂量的MDMA对T没有严重影响，相反，相同剂量的MDMA足以引起危及生命的高热。神经化学研究显示，甲状腺功能亢进大鼠的5-羟色胺外排高于甲状腺功能正常大鼠。这些作用可通过预处理5-HT2A受体拮抗剂M100907阻断。总之，我们的数据支持这样的假设:甲亢患者在服用MDMA后更容易出现严重的血清素综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of forensic research and analysis

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