[A Novel Inhibitory Factor of Erythropoietin: Anti-Erythropoietin Receptor Antibody and Its Characteristics].

Akinori Hara, Takashi Wada
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Abstract

During the exploration of factors that interfere with the erythropoietin (EPO) -EPO receptor (EPOR) interaction in anemia, a novel inhibitory factor of EPO, anti-EPOR antibody, has been detected in anemic pa- tients with immune-mediated diseases. The study also demonstrated that the antibodies were observed in some patients with chronic kidney disease (CKD). EPOR is known to be expressed not only in bone mar- row erythroblasts, but also in other organs including the kidneys. In addition, previous studies showed that EPO may contribute to protecting the kidneys from injury by binding EPOR on renal resident cells as well as through the correction of anemia. Based on this background, we recently examined the clinical significance of anti-EPOR antibodies in patients with CKD. With regard to patients with lupus nephritis, who showed the highest antibody levels among the patients examined, the antibodies were associated with overall disease activity and cell infiltration in the injured kidney, and they were inversely related to the preserved renal function. Here, we discuss the discovery of anti-EPOR antibodies in patients with anemia and CKD, and the possibil- ity of their use as an additional biomarker for the deterioration of the renal function. [Review].

[一种新的促红细胞生成素抑制因子:抗促红细胞生成素受体抗体及其特性]。
在探讨红细胞生成素(EPO) -EPO受体(EPOR)在贫血中相互作用的影响因素时,在免疫介导性疾病的贫血患者中发现了一种新的EPO抑制因子——抗EPOR抗体。该研究还表明,在一些慢性肾脏疾病(CKD)患者中观察到抗体。众所周知,EPOR不仅在骨髓红母细胞中表达,也在包括肾脏在内的其他器官中表达。此外,既往研究表明,EPO可能通过与肾常驻细胞结合以及通过纠正贫血来保护肾脏免受损伤。基于这一背景,我们最近研究了抗epor抗体在CKD患者中的临床意义。狼疮性肾炎患者的抗体水平在检查的患者中最高,抗体与整体疾病活动性和受损肾脏的细胞浸润相关,与保留的肾功能呈负相关。在这里,我们讨论了在贫血和CKD患者中发现的抗epor抗体,以及它们作为肾功能恶化的额外生物标志物的可能性。(审查)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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