[Investigation of the Renal Function Evaluation in the Living Donor Renal Transplantation Candidate at Our Center].

Koichi Kozaki
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Abstract

In Japan, the number of living renal transplant donors with medical complications has been increasing in recent years due to the.aging of donors. It is important to assess donor renal function properly before donation to ensure donor safety. This study aimed to assess different renal function measures of donors, includ- ing serum creatinine (Cr), creatinine clearance (Ccr), estimated glomerular filtration rate (eGFR), and inulin clearance (Cin). The mean Cr and eGFR values of 64 donors before surgery and at 1 month, 1 year, and 3 years after surgery were 0.74, 1.15, 1.13, and 1.05 mg/dL, respectively, and 71.7, 42.4, 44.9, and 49.5 mL/min/1.73m2, respectively. Values of eGFR 3 years after surgery in 20 out of 36 donors (55.6%) were less than 50 mL/min/1.73m2, showing that moderately decreased levels of GFR persist for a long time after donation. The preoperative renal function of 20 candidate donors was evaluated based on Cr, Ccr, eGFR, and Cin. The mean preoperative values were Cr 0.74 mg/dL, eGFR 71.9 mL/min/1.73m2, Ccr 137.3 mL/min, and Cin 92.9 mL/min. Ccr overestimated Cin in 18 out of 20 donors (90%) and eGFR underestimated Cin in 16 donors (80%). Cin measurements are complicated, which can lead to human errors in measurement. Conversely, eGFR measurements are simple but are inferior to Cin in terms of accuracy; therefore, the pre- operative renal function of donors should be evaluated by Cin, combined with other tests as much as possible to ensure a safe living renal transplant. [Original].

[我中心活体肾移植候选者肾功能评价调查]。
在日本,近年来有医疗并发症的活体肾移植供体的数量一直在增加。捐赠者老龄化。捐献前正确评估供者肾功能,确保供者安全是很重要的。本研究旨在评估供者的不同肾功能指标,包括血清肌酐(Cr)、肌酐清除率(Ccr)、估计肾小球滤过率(eGFR)和菊粉清除率(Cin)。64例供者术前、术后1个月、1年、3年Cr、eGFR均值分别为0.74、1.15、1.13、1.05 mg/dL, 71.7、42.4、44.9、49.5 mL/min/1.73m2。36例献血者中有20例(55.6%)术后3年eGFR值小于50 mL/min/1.73m2,表明捐献后GFR中度下降持续时间较长。根据Cr、Ccr、eGFR和Cin评估20例候选供者的术前肾功能。术前平均值Cr为0.74 mg/dL, eGFR为71.9 mL/min/1.73m2, Ccr为137.3 mL/min, Cin为92.9 mL/min。20名献血者中,Ccr高估了18名(90%),eGFR低估了16名(80%)。中国的测量是复杂的,这可能导致人为误差的测量。相反,eGFR测量简单,但在准确性方面不如中国;因此,术前应对供者进行肾功能评估,并尽可能结合其他检查,以确保安全的活体肾移植。(最初的)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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