{"title":"[DIFFERENCES OF EXENATIDE EFFECTS ON GLYCEMIA AND RENAL WATER AND ION EXCRETION IN FROGS AND RATS].","authors":"A V Kutina, A S Marina, Yu V Natochin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of the present study was to compare effects of glucagon-like peptide-1 (GLP-1) mimetic exenatide on glucose and water-salt homeostasis in animals with different level of renal tubular proximal reabsorption - rats (Rattus norvegicus) and frogs (Rana temporaria). Following glucose tolerance test, in rats exenatide promoted rapid recovery of normoglycemia, whereas in frogs delayed this process. In water-loaded rats exenatide essentially augmented solute-free water clearance and enhanced natriuresis in furosemide-treated rats.-In frogs exenatide did not alter urinary flow rate, urinary sodium excretion and solute-free water clearance under water diuresis and furosemide treatment. It is suggested that the invol- vement of GLP- 1 in regulation of water-salt homeostasis in mammals should be preceded by key evoluti- onary transformation - increase in glomerular filtration rate and proximal tubular reabsorption.</p>","PeriodicalId":24017,"journal":{"name":"Zhurnal evoliutsionnoi biokhimii i fiziologii","volume":"52 2","pages":"205-213"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal evoliutsionnoi biokhimii i fiziologii","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The aim of the present study was to compare effects of glucagon-like peptide-1 (GLP-1) mimetic exenatide on glucose and water-salt homeostasis in animals with different level of renal tubular proximal reabsorption - rats (Rattus norvegicus) and frogs (Rana temporaria). Following glucose tolerance test, in rats exenatide promoted rapid recovery of normoglycemia, whereas in frogs delayed this process. In water-loaded rats exenatide essentially augmented solute-free water clearance and enhanced natriuresis in furosemide-treated rats.-In frogs exenatide did not alter urinary flow rate, urinary sodium excretion and solute-free water clearance under water diuresis and furosemide treatment. It is suggested that the invol- vement of GLP- 1 in regulation of water-salt homeostasis in mammals should be preceded by key evoluti- onary transformation - increase in glomerular filtration rate and proximal tubular reabsorption.
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