[Validation of Whole Slide Imaging for Primary Diagnosis of Gastrointestinal Pathology].

Akihiko Yoshizawa, Mitsuru Tanaka
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Abstract

Whole-slide imaging (WSI) technology enables the primary diagnosis of histopathological slides. This study aimed to determine the diagnostic concordance between pathological interpretations made using WSI and those made using light microscopy (LM). For this study, 5,704 consecutive surgical pathological cases from a community hospital were included. The specimens were digitized at x40 magnification for biopsy and endoscopic resection specimens or at x20 magnification for other specimens and evaluated by 11 pathologists for diagnosis using WSI. Subsequently, the specimens were signed out using LM by 3 pathologists after 2 weeks. Diagnoses using WSI were then compared with the diagnoses made by using LM. Most (96.8%) of the 5,704 specimens were obtained from the gastrointestinal tract (2,441 biopsy specimens from the esophagogastroduodenum [42.7%], 1,678 endoscopic resection specimens from the colorectum [29.4%], 1,349 biopsy specimens from the colorectum [23.6%], 133 resected specimens from the gallbladder [2.3%], 56 endoscopic resection specimens from the stomach [0.9%], 30 resected specimens from the ap- pendix [0.5%], 14 skin biopsy specimens [0.2%], and 3 other specimens [0.1%]). The overall concordance between the diagnoses made using WSI and those made using LM was 95.1%. The major and minor dis- crepancy rates for WSI were 0.1% and 4.8%, respectively. None of the discordant cases had any clinical or prognostic implications. In conclusion, this study revealed that WSI can be used for primary diagnosis of gastrointestinal biopsy and endoscopic resection specimens. To the best of our knowledge, this is one of the studies that clearly proved that diagnosis using WSI is equivalent to diagnosis using LM. [Original].

【全玻片成像对胃肠道病理初步诊断的验证】。
全玻片成像(WSI)技术能够对组织病理学玻片进行初步诊断。本研究旨在确定WSI病理解释与光学显微镜病理解释之间的诊断一致性。本研究纳入某社区医院5704例连续手术病理病例。活检和内镜切除标本在x40倍放大镜下数字化,其他标本在x20倍放大镜下数字化,并由11名病理学家评估WSI诊断。2周后由3名病理学家用LM签出标本。然后将WSI诊断与LM诊断进行比较。5704例标本中绝大多数(96.8%)来自胃肠道(食管胃十二指肠活检2441例(42.7%),结肠内镜切除1678例(29.4%),结肠活检1349例(23.6%),胆囊切除133例(2.3%),胃内镜切除56例(0.9%),阑尾切除30例(0.5%),皮肤活检14例(0.2%),其他3例(0.1%))。WSI诊断与LM诊断的总体一致性为95.1%。WSI的主要和次要差异率分别为0.1%和4.8%。没有任何不一致的病例有任何临床或预后意义。综上所述,本研究显示WSI可用于胃肠道活检和内镜切除标本的初步诊断。据我们所知,这是明确证明使用WSI诊断等同于使用LM诊断的研究之一。(最初的)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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