[New Horizon in Clinical Examination -Chairmen's Introductory Remarks -].

Kaname Nakatani, Takashi Ishikawa
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Abstract

Translational research is leading to new technology and generating in practical diagnostic tests with clinical utility. This paper introduces three cutting-edge technologies: liquid biopsy, amino acid profiling, and con- tinuous glucose monitoring (CGM). Liquid biopsy was reviewed as one of the "10 Breakthrough Technologies in 2015" by MIT. This technol- ogy is based on fast DNA-sequencing machines or high-sensitivity PCR and non-invasive tests that detect fragments of DNA or cells in blood or other bodily fluids. Cell-free DNA refers to segments of DNA that are mainly derived from apoptotic and necrotic cells, and it is used for the detection and monitoring of cancer. Profiling of plasma-free amino acid is a promising approach because amino acid profiling links all organ sys- tems and amino acids have important roles in metabolism. Furthermore, amino acid profiles are known to be influenced by specific diseases, including cancers. CGM systems use a tiny sensor inserted under the skin to continuously check glucose levels in tissue fluid and convert blood glucose levels. CGM can provide valuable information at any points during the day and facilitate better treatment decisions and glucose control. [Review].

[临床检查新视野-主席导言-]。
转化研究正在引领新技术并产生具有临床效用的实际诊断测试。本文介绍了三种前沿技术:液体活检、氨基酸谱分析和连续血糖监测(CGM)。液体活检被麻省理工学院评为“2015年十大突破性技术”之一。这项技术是基于快速DNA测序仪或高灵敏度PCR和非侵入性检测,检测血液或其他体液中的DNA片段或细胞。无细胞DNA是指主要来源于凋亡和坏死细胞的DNA片段,用于癌症的检测和监测。血浆游离氨基酸谱分析是一种很有前途的方法,因为氨基酸谱分析连接了所有器官系统,氨基酸在代谢中具有重要作用。此外,氨基酸谱已知会受到特定疾病的影响,包括癌症。CGM系统使用一个插入皮肤下的微小传感器来连续检查组织液中的葡萄糖水平并转换血糖水平。CGM可以在一天中的任何时间点提供有价值的信息,促进更好的治疗决策和血糖控制。(审查)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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