[Therapeutic Drug Monitoring of Antimicrobial Agents].

Shota Kadomura
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引用次数: 0

Abstract

Antimicrobial dosing can be targeted to achieve pharmacokinetic (PK) -pharmacodynamic parameters at the minimal inhibitory concentration of bacteria. Therapeutic drug monitoring (TDM) of glycopetides [vanco- mycin (VCM) and teicoplanin] and aminoglycosides (gentamicin, tobramycin, and amikacin) makes it possible to optimize dosing in individual patients. TDM of these antimicrobials can improve clinical outcomes, de- crease adverse events, and reduce costs. Therefore, PK-monitoring for VCM and aminoglycosides is rec- ommended in the Antimicrobial Stewardship Program implementing guidelines developed by the Infectious Disease Society of America and the Society for Healthcare Epidemiology of America in 2016. In addition, Clinical practice guidelines for TDM have been developed by the Japanese Society of Chemotherapy and the Japanese Society of TDM since 2012, and they were updated in 2016. The aim of this study was to review TDM of antimicrobial agents. [Review].

[抗菌药物治疗药物监测]。
抗菌药物的剂量可以有针对性地达到最低细菌抑制浓度下的药代动力学(PK) -药效学参数。治疗药物监测(TDM)的糖苷类[万古霉素(VCM)和替柯planin]和氨基糖苷类(庆大霉素,妥布霉素和阿米卡星),使其有可能优化个别患者的剂量。这些抗菌剂的TDM可以改善临床结果,减少不良事件,并降低成本。因此,美国传染病学会和美国卫生保健流行病学学会在2016年制定的抗菌药物管理计划实施指南中推荐对VCM和氨基糖苷进行pk监测。此外,日本化疗学会和日本TDM学会自2012年起制定了TDM临床实践指南,并于2016年进行了更新。本研究的目的是综述抗菌药物的TDM。(审查)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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