Effect of Vitamin D on Cognitive Functions in Older Adults: 24-Week Follow-Up Study.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-03-01 Epub Date: 2019-01-01 DOI:10.1177/1533317518822274

Esra Ates Bulut, Pinar Soysal, Idil Yavuz, Suleyman Emre Kocyigit, Ahmet Turan Isik

{"title":"Effect of Vitamin D on Cognitive Functions in Older Adults: 24-Week Follow-Up Study.","authors":"Esra Ates Bulut, Pinar Soysal, Idil Yavuz, Suleyman Emre Kocyigit, Ahmet Turan Isik","doi":"10.1177/1533317518822274","DOIUrl":null,"url":null,"abstract":"The purpose of this study is to assess the effect of vitamin D replacement on cognitive function in older adults. A total of 560 patients who underwent comprehensive geriatric assessment including Global cognitive assessment, Basic Activities of Daily Living (BADL), and Instrumental Activities of Daily Living (IADL) twice in 6-month period were retrospectively reviewed. Oral cholecalciferol was replaced to patients with vitamin D deficiency routinely. In baseline cognitive scores, BADL-IADL scores were lower in the severe deficiency group than in the deficiency and adequate groups (P < .05). With regard to the relation between changes in cognitive functions, BADL-IADL scores on the 6-month versus baseline, no difference was determined in patients with and without dementia (P > .05). Vitamin D replacement may not improve cognitive performance in older adults, even if vitamin D is raised to adequate level, suggesting that longer term replacement therapy may be needed to improve cognitive function.","PeriodicalId":50816,"journal":{"name":"American Journal of Alzheimers Disease and Other Dementias","volume":"34 2","pages":"112-117"},"PeriodicalIF":2.7000,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852460/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Alzheimers Disease and Other Dementias","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1533317518822274","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The purpose of this study is to assess the effect of vitamin D replacement on cognitive function in older adults. A total of 560 patients who underwent comprehensive geriatric assessment including Global cognitive assessment, Basic Activities of Daily Living (BADL), and Instrumental Activities of Daily Living (IADL) twice in 6-month period were retrospectively reviewed. Oral cholecalciferol was replaced to patients with vitamin D deficiency routinely. In baseline cognitive scores, BADL-IADL scores were lower in the severe deficiency group than in the deficiency and adequate groups (P < .05). With regard to the relation between changes in cognitive functions, BADL-IADL scores on the 6-month versus baseline, no difference was determined in patients with and without dementia (P > .05). Vitamin D replacement may not improve cognitive performance in older adults, even if vitamin D is raised to adequate level, suggesting that longer term replacement therapy may be needed to improve cognitive function.

查看原文本刊更多论文

维生素 D 对老年人认知功能的影响：24 周随访研究。

本研究旨在评估维生素 D 补充剂对老年人认知功能的影响。研究人员对 560 名在 6 个月内接受过两次全面老年评估（包括全球认知评估、基本日常生活活动（BADL）和工具性日常生活活动（IADL））的患者进行了回顾性回顾。为维生素 D 缺乏症患者常规补充口服胆钙化醇。在基线认知评分中，严重缺乏组的 BADL-IADL 评分低于缺乏组和充足组（P < .05）。至于认知功能的变化、6个月的BADL-IADL评分与基线评分之间的关系，在痴呆症患者和非痴呆症患者中没有发现差异（P > .05）。即使维生素 D 的含量提高到足够的水平，维生素 D 的替代品也可能无法改善老年人的认知能力，这表明可能需要更长期的替代疗法来改善认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).