Risk factors for acute coronary syndrome in patients below the age of 40 years

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Egyptian Heart Journal Pub Date : 2018-12-01 DOI:10.1016/j.ehj.2018.05.005

Aram J. Mirza , Abdulsalam Y. Taha , Bahar R. Khdhir

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引用次数: 36

Abstract

Background

Acute coronary syndrome (ACS) refers to a spectrum of symptoms compatible with acute myocardial ischemia. Plasma markers of inflammation have been recently identified as diagnostic aid and risk predictors. The present study, conducted in Slemani Cardiac Hospital (SCH), Sulaimaniyah, Iraq aimed to recognize some risk factors for ACS in Iraqi adults younger than 40.

Methodology

This is a prospective case-control study of 100 patients with ACS vs. a control group of 100 healthy volunteers. The study began at 1st January 2014 and ended at 31st December 2016. All patients were subjected to full history taking, clinical examination including measurement of waist circumference and body mass index (BMI). Investigations included electrocardiography (ECG), echocardiography, full blood count, measurement of lipid profile and C-reactive protein (CRP). The patients were managed by percutaneous coronary intervention (PCI).

Results

The mean age of the patients was 36 years (range 28–40). Eighty-five% of patients were male. The mean BMI (29 kg/m²) and waist circumference (98 cm) of the patients were higher than the controls (24 kg/m² and 72 cm respectively). The leukocytes, lymphocytes and neutrophil counts as well as CRP in both groups were within the normal range. The most prevalent risk factor was obesity (n = 86). Other risk factors were smoking (n = 62), hypertension (n = 26), diabetes mellitus (n = 22) and positive family history of ACS (n = 24). Most patients (n = 83) had multi-vessel coronary artery disease (2–3 vessels).

Conclusion

ACS in young adults is an increasing health problem. Obesity was found to be the most prevalent risk factor.

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40岁以下患者急性冠状动脉综合征的危险因素

背景:急性冠脉综合征(ACS)是指一系列与急性心肌缺血相适应的症状。血浆炎症标志物最近被确定为诊断辅助和风险预测因子。本研究在伊拉克苏莱曼尼亚的Slemani心脏医院(SCH)进行，旨在识别伊拉克40岁以下成年人发生ACS的一些危险因素。这是一项前瞻性病例对照研究，研究对象为100名ACS患者和100名健康志愿者。研究于2014年1月1日开始，2016年12月31日结束。所有患者均接受了完整的病史记录，临床检查包括测量腰围和身体质量指数(BMI)。调查包括心电图(ECG)、超声心动图、全血细胞计数、血脂和c反应蛋白(CRP)测量。患者均行经皮冠状动脉介入治疗(PCI)。结果患者平均年龄36 岁(28 ~ 40岁)。85%的患者为男性。患者的平均BMI(29 kg/m2)和腰围(98 cm)均高于对照组(24 kg/m2和72 cm)。两组患者白细胞、淋巴细胞、中性粒细胞计数及CRP均在正常范围内。最普遍的危险因素是肥胖(n = 86)。其他危险因素为吸烟(n = 62)、高血压(n = 26)、糖尿病(n = 22)和ACS家族史(n = 24)。多数患者(n = 83)为多支冠状动脉病变(2-3支)。结论青壮年acs是一个日益严重的健康问题。肥胖被发现是最普遍的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Egyptian Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Egyptian Heart Journal is the official journal of the Egyptian Society of Cardiology. It is an international journal that publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies and translational investigations. The journal publishes research, review articles, case reports and commentary articles, as well as editorials interpreting and commenting on the research presented. In addition, it provides a forum for the exchange of information on all aspects of cardiovascular medicine, including educational issues.