The Effect of Periarticular Injection of Methylprednisolone Acetate in Patients with Primary Osteoarthritis of the Proximal Interphalangeal Joints: A Case Controlled Study.

Q2 Medicine
Pain Research and Treatment Pub Date : 2018-11-14 eCollection Date: 2018-01-01 DOI:10.1155/2018/7561209
George Habib, Fahed Sakas, Suheil Artul, Fadi Khazin
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引用次数: 5

Abstract

Backgrounds: Primary osteoarthritis of the proximal interphalangeal joints (PIPJ) is a common entity. It could be associated with local pain that has no effective treatment. Local subcutaneous periarticular injection of methylprednisolone acetate (MPA) was evaluated in a prospective case-control study.

Methods: Patients with painful osteoarthritis of the PIPJ for more than 1 month not responding to nonsteroidal meds were prospectively recruited. Radiographic, demographic, clinical, and lab parameters were documented. Visual analogue scale (VAS) was documented regarding the level of PIPJ pain prior to the injection. Patients had local subcutaneous periarticular injection at the medial and lateral sides of each painful PIPJ of one hand, of 8 mg (0.2 ml) of MPA mixed with 0.1 ml of lidocaine 1% (group 1) at each side. Age- and sex-matched control group were given 0.3 ml of normal saline using the same approach (group 2) at each side. VAS was evaluated 1, 4, and 10 weeks following the injection and compared to baseline levels using Wilcoxon's ranks signed test.

Results: Eighteen and sixteen patients were recruited in group 1 and group 2, respectively. There were 11 females in group 1 with mean age of 52.7 ± 9.2 years. Mean VAS in group 1 at baseline was 67 and at weeks 1, 4, and 10 was 23 (p=0.001), 29 (p=0.001), and 55 (p=0.043), respectively. Mean VAS in group 2 at baseline was 65 and at weeks 1, 4, and 10 was 43 (p=0.005), 64 (p=0.534), and 69 (0.698), respectively.

Conclusions: Subcutaneous periarticular injection of MPA + lidocaine at the PIP joints resulted in a small but significant improvement that gradually diminished with time across the week 10, among patients with primary OA of hands.

Abstract Image

关节周围注射醋酸甲泼尼龙治疗原发性近端指间关节骨性关节炎的疗效:一项病例对照研究。
背景:原发性近端指间关节骨性关节炎(PIPJ)是一种常见的疾病。它可能与局部疼痛有关,没有有效的治疗方法。在一项前瞻性病例对照研究中评估了局部关节周围皮下注射醋酸甲基强的松龙(MPA)。方法:前瞻性招募PIPJ疼痛性骨关节炎患者1个月以上,非甾体药物治疗无效。记录了影像学、人口学、临床和实验室参数。视觉模拟评分(VAS)记录了注射前PIPJ疼痛的水平。患者单侧疼痛PIPJ内侧和外侧局部皮下注射MPA 8 mg (0.2 ml),每侧混合1%利多卡因0.1 ml(1组)。年龄和性别匹配的对照组采用相同的方法,每侧给予生理盐水0.3 ml(第二组)。VAS在注射后1、4和10周进行评估,并使用Wilcoxon's rank sign test与基线水平进行比较。结果:1组18例,2组16例。1组女性11例,平均年龄52.7±9.2岁。第一组在基线时的平均VAS为67,在第1、4和10周时分别为23 (p=0.001)、29 (p=0.001)和55 (p=0.043)。2组患者基线时平均VAS为65,第1、4、10周时平均VAS分别为43 (p=0.005)、64 (p=0.534)、69(0.698)。结论:在手部原发性OA患者中,在PIP关节处皮下注射MPA +利多卡因可导致小而显著的改善,并随着时间的推移逐渐减弱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
自引率
0.00%
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