{"title":"The association between preeclampsia and autism spectrum disorders among children: a meta-analysis.","authors":"Ensiyeh Jenabi, Manoochehr Karami, Salman Khazaei, Saeid Bashirian","doi":"10.3345/kjp.2018.07010","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This meta-analysis pooled relevant case-control and cohort studies to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.</p><p><strong>Methods: </strong>The search for relevant studies in major databases was performed, which included Web of Science, PubMed, and Scopus up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among the studies.</p><p><strong>Results: </strong>The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD (OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41).</p><p><strong>Conclusions: </strong>Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.</p>","PeriodicalId":17863,"journal":{"name":"Korean Journal of Pediatrics","volume":"62 4","pages":"126-130"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/72/kjp-2018-07010.PMC6477549.pdf","citationCount":"24","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3345/kjp.2018.07010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/12/24 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 24
Abstract
Purpose: This meta-analysis pooled relevant case-control and cohort studies to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods: The search for relevant studies in major databases was performed, which included Web of Science, PubMed, and Scopus up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among the studies.
Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD (OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41).
Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.
期刊介绍：
Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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