Adaptation of Candida albicans during gastrointestinal tract colonization.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2018-09-01 Epub Date: 2018-06-16 DOI:10.1007/s40588-018-0096-8

Animesh A Mishra, Andrew Y Koh

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引用次数: 17

Abstract

Purpose of review: Colonization of the gastrointestinal (GI) tract with Candida albicans (CA), the most common human fungal pathogen, is the first step towards the development of invasive infection. Yet the fungal virulence factors and host factors that modulate CA GI colonization are still poorly understood. In this review, we will review emerging evidence of the importance of select CA genetic determinants and CA's interaction with the host that contribute to its successful adaptation as a pathobiont in the human GI tract.

Recent findings: Recent data reveal the importance of 1) CA genetic determinants; 2) host factors; and 3) environmental factors in modulating CA GI colonization in humans.

Summary: As evidence continues to grow supporting the notion that the GI tract and its resident microbiota are an integral part of the host immune system, it will be critical for studies to interrogate the interaction of CA with the host (including both the host innate and adaptive immune system as well as the endogenous gut microbiota) in order to dissect the mechanisms of CA pathogenesis and thus lay the foundation for novel therapeutic approaches to prevent and/or treat invasive fungal infections.

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白色念珠菌在胃肠道定植过程中的适应性。

综述目的:人类最常见的真菌病原体白色念珠菌(CA)在胃肠道(GI)中的定植是侵袭性感染发展的第一步。然而，调节CA - GI定植的真菌毒力因子和宿主因子仍然知之甚少。在这篇综述中，我们将回顾新出现的证据，这些证据表明CA遗传决定因素的重要性以及CA与宿主的相互作用有助于其成功适应人类胃肠道中的病原体。最近的发现:最近的数据揭示了1)CA遗传决定因素的重要性;2)宿主因素;3)环境因素对人体内CA - GI定植的调节作用。简介:作为证据支持继续增长的胃肠道微生物群和它的居民是宿主免疫系统不可分割的一部分,这将是研究的关键审问CA与宿主之间的相互作用(包括主持人先天和适应性免疫系统以及内生的肠道微生物群)为了解剖CA发病机制,从而为新型治疗方法奠定基础预防和/或治疗侵袭性真菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.