Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity.

Korean Journal of Pediatrics Pub Date : 2019-02-01 Epub Date: 2018-11-23 DOI:10.3345/kjp.2018.06639
Ki Eun Kim, Kyung Suk Baek, Sol Han, Jung Hyun Kim, Youn Ho Shin
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引用次数: 2

Abstract

Purpose Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods A population of 120 apparently healthy adolescents aged 12–13 years was included in the cross-sectional design study; 58 were overweight or obese and 62 were of normal weight. We estimated anthropometric and laboratory measurements, including waist-to-height ratio, blood pressure, insulin sensitivity, aspartate aminotransferases (AST), ALT, and lipid profiles. Results The mean ages of the overweight or obese and normal weight participants were 12.9±0.3 and 13.0±0.3 years, respectively. Height, weight, body mass index, waist circumference, waist-to-height ratio, systolic and diastolic blood pressure, AST, ALT, total cholesterol, low-density lipoprotein-cholesterol, triglyceride, insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) score were significantly higher and the high-density lipoprotein-cholesterol and quantitative insulin-sensitivity check index were significantly lower in the overweight/obese participants in comparison to the normal-weight participants (all P<0.05). In multivariate linear regression analysis, waist-to-height ratio, systolic blood pressure, and HOMA-IR score were independently and positively associated with serum ALT levels. Conclusion Screening for ALT levels in adolescents may help to differentiate those at risk of metabolic abnormalities and thus prevent disease progression at an early age.

Abstract Image

血清丙氨酸转氨酶水平与代谢紊乱密切相关在明显健康的青少年独立于肥胖。
目的:肝脏代谢在代谢性疾病的发生发展中起着关键作用。我们的目的是调查韩国城市青少年中与谷丙转氨酶(ALT)水平相关的临床和实验室危险因素。方法:采用横断面设计研究,选取120例12 ~ 13岁表面健康的青少年;其中58人超重或肥胖,62人体重正常。我们估计了人体测量和实验室测量,包括腰高比、血压、胰岛素敏感性、天冬氨酸转氨酶(AST)、ALT和脂质谱。结果:超重或肥胖和正常体重参与者的平均年龄分别为12.9±0.3岁和13.0±0.3岁。身高、体重、体重指数、腰围、腰高比、收缩压和舒张压、AST、ALT、总胆固醇、低密度脂蛋白-胆固醇、甘油三酯、胰岛素、超重/肥胖受试者的胰岛素抵抗稳态模型评估(HOMA-IR)评分显著高于正常体重受试者,高密度脂蛋白-胆固醇和定量胰岛素敏感性检查指数显著低于正常体重受试者。结论:筛查青少年ALT水平有助于区分代谢异常风险,从而在早期预防疾病进展。
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来源期刊
自引率
0.00%
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0
审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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