Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2019-01-01 DOI:10.1016/j.biotechadv.2018.11.008

Mirela Teodorescu, Maria Bercea, Simona Morariu

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引用次数: 242

Abstract

Poly(vinyl alcohol) (PVA) has attracted considerable research interest and is recognized among the largest volume of synthetic polymers that have been produced worldwide for almost one century. This is due to its exceptional properties which dictated its extensive use in a wide variety of applications, especially in medical and pharmaceutical fields. However, studies revealed that PVA-based biomaterials present some limitations that can restrict their use or performances. To overcome these limitations, various methods have been reported, among which blending with poly(vinylpyrrolidone) (PVP) showed promising results. Thus, our aim was to offer a systematic overview on the current state concerning the preparation, properties and various applications of biomaterials based on synergistic effect of mixtures between PVA and PVP. Future trends towards where the biomaterials research is headed were discussed, showing the promising opportunities that PVA and PVP can offer.

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PVA和PVP生物材料在医疗和制药中的应用:前景和挑战

聚乙烯醇(PVA)引起了相当大的研究兴趣，是近一个世纪以来世界范围内产量最大的合成聚合物之一。这是由于其特殊的性质，这决定了它在各种各样的应用，特别是在医疗和制药领域的广泛使用。然而，研究表明，pva基生物材料存在一些局限性，限制了它们的使用或性能。为了克服这些限制，人们报道了各种方法，其中与聚乙烯吡咯烷酮(PVP)共混取得了良好的效果。因此，我们的目的是对基于PVA和PVP混合物协同效应的生物材料的制备、性能和各种应用的现状进行系统的概述。讨论了生物材料研究的未来趋势，展示了PVA和PVP可以提供的有希望的机会。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.