The Influence of Type 2 Diabetes Mellitus on the Osseointegration of Titanium Implants With Different Surface Modifications-A Histomorphometric Study in High-Fat Diet/Low-Dose Streptozotocin-Treated Rats.

3区医学 Q1 Dentistry

Implant Dentistry Pub Date : 2019-02-01 DOI:10.1097/ID.0000000000000836

Wenjuan Zhou, Stefan Tangl, Karoline Maria Reich, Franziska Kirchweger, Zhonghao Liu, Werner Zechner, Christian Ulm, Xiaohui Rausch-Fan

{"title":"The Influence of Type 2 Diabetes Mellitus on the Osseointegration of Titanium Implants With Different Surface Modifications-A Histomorphometric Study in High-Fat Diet/Low-Dose Streptozotocin-Treated Rats.","authors":"Wenjuan Zhou, Stefan Tangl, Karoline Maria Reich, Franziska Kirchweger, Zhonghao Liu, Werner Zechner, Christian Ulm, Xiaohui Rausch-Fan","doi":"10.1097/ID.0000000000000836","DOIUrl":null,"url":null,"abstract":"Objectives: Type 2 diabetes mellitus (T2DM) is a systemic disease that also compromises the bone healing capacity. In healthy individuals, surface modifications of dental implants are proven to increase bone response and implant success. The aim of this study was to clarify if the surface modifications also improve osseointegration in a setting with diabetes mellitus.Methods: T2DM was induced in 7 rats by a high-fat diet/low-dose streptozotocin injection. All animals received a hydroxyapatite (HA) implant, a sandblasted and acid-etched (SLA) implant, and a standard machined titanium implant for control in the tibia. After 4 weeks, thin-ground sections were produced, and the volume of new bone formation (nBV/TV) and bone-to-implant contact (nB.I/Im.I) were histomorphometrically analyzed.Results: Both surface modifications led to an increase of osseointegration compared with the machined surface implant in rats with T2DM. nBV/TV was highest in the SLA implants, whereas nB.I/Im.I was highest in the HA group. Regardless of the surface modification, a superordinate regional pattern of new bone formation over the length of the implant was observed.Conclusions: Implants with HA coating and SLA surface modifications seem to have the potential to increase osseointegration also in T2DM rats when compared with a conventional machined surface.","PeriodicalId":13309,"journal":{"name":"Implant Dentistry","volume":"28 1","pages":"11-19"},"PeriodicalIF":0.0000,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/ID.0000000000000836","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Implant Dentistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/ID.0000000000000836","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Dentistry","Score":null,"Total":0}

引用次数: 9

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) is a systemic disease that also compromises the bone healing capacity. In healthy individuals, surface modifications of dental implants are proven to increase bone response and implant success. The aim of this study was to clarify if the surface modifications also improve osseointegration in a setting with diabetes mellitus.

Methods: T2DM was induced in 7 rats by a high-fat diet/low-dose streptozotocin injection. All animals received a hydroxyapatite (HA) implant, a sandblasted and acid-etched (SLA) implant, and a standard machined titanium implant for control in the tibia. After 4 weeks, thin-ground sections were produced, and the volume of new bone formation (nBV/TV) and bone-to-implant contact (nB.I/Im.I) were histomorphometrically analyzed.

Results: Both surface modifications led to an increase of osseointegration compared with the machined surface implant in rats with T2DM. nBV/TV was highest in the SLA implants, whereas nB.I/Im.I was highest in the HA group. Regardless of the surface modification, a superordinate regional pattern of new bone formation over the length of the implant was observed.

Conclusions: Implants with HA coating and SLA surface modifications seem to have the potential to increase osseointegration also in T2DM rats when compared with a conventional machined surface.

查看原文本刊更多论文

2型糖尿病对不同表面修饰钛种植体骨整合的影响——高脂肪饮食/低剂量链脲佐菌素治疗大鼠的组织形态学研究

目的:2型糖尿病(T2DM)是一种损害骨愈合能力的全身性疾病。在健康个体中，牙种植体的表面修饰被证明可以增加骨反应和种植成功。本研究的目的是澄清表面修饰是否也能改善糖尿病患者的骨整合。方法:采用高脂饮食/低剂量链脲佐菌素注射诱导7只大鼠T2DM。所有的动物都接受了羟基磷灰石(HA)种植体、喷砂酸蚀(SLA)种植体和标准的加工钛种植体来控制胫骨。4周后，制作薄磨切片，对新生骨形成体积(nBV/TV)和骨与种植体接触量(nbi / imi)进行组织形态学分析。结果:与机械表面种植体相比，两种表面修饰均能增加T2DM大鼠的骨整合。nBV/TV在SLA植入物中最高;我在HA组中是最高的。无论表面修饰如何，在种植体长度上观察到新骨形成的优越区域模式。结论:与传统的机械表面相比，HA涂层和SLA表面修饰的种植体似乎也有可能增加T2DM大鼠的骨整合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Implant Dentistry 医学-牙科与口腔外科

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cessation. Implant Dentistry, an interdisciplinary forum for general practitioners, specialists, educators, and researchers, publishes relevant clinical, educational, and research articles that document current concepts of oral implantology in sections on biomaterials, clinical reports, oral and maxillofacial surgery, oral pathology, periodontics, prosthodontics, and research. The journal includes guest editorials, letters to the editor, book reviews, abstracts of current literature, and news of sponsoring societies.