Ketamine and magnesium common pathway of antidepressant action.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Natalia Górska, Wiesław Jerzy Cubała, Jakub Słupski, Maria Gałuszko-Węgielnik
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引用次数: 4

Abstract

Depression is one of the major causes of disability worldwide. A proportion of adults with major depression fail to achieve remission with first-line treatment. Magnesium influences the neurotransmission involved in emotional processes, such as the serotonergic, noradrenergic, dopaminergic, GABAergic and glutamatergic systems. It has been reported that the mechanism of antidepressants' action is involved in the glutamatergic system. Theories about the role of magnesium ions in pathophysiology of major depressive disorder include blocking the glutamatergic N-methyl-D-aspartate receptor (NMDAR). Ketamine, NMDAR antagonist, was found to promote fast-acting antidepressant and antisuicidal effects. Magnesium and ketamine seem to be involved in key mechanisms of the major depression pathophysiology. The evidence in the paper discussed may indicate the synergistic interaction between magnesium and ketamine pharmacodynamic activity being of particular importance in mood disorders.

氯胺酮和镁是抗抑郁作用的共同途径。
抑郁症是全世界致残的主要原因之一。有一部分成人重度抑郁症患者在接受一线治疗后未能获得缓解。镁影响情绪过程中的神经传递,如血清素能、去甲肾上腺素能、多巴胺能、gaba能和谷氨酸能系统。据报道,抗抑郁药的作用机制涉及谷氨酸系统。关于镁离子在重度抑郁症病理生理中的作用的理论包括阻断谷氨酸能n -甲基- d -天冬氨酸受体(NMDAR)。氯胺酮,NMDAR拮抗剂,被发现促进速效抗抑郁和抗自杀作用。镁和氯胺酮似乎参与了重度抑郁症病理生理的关键机制。本文讨论的证据可能表明,镁和氯胺酮的药效学活性之间的协同相互作用在情绪障碍中特别重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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