The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.

IF 1.7 Q4 NEUROSCIENCES

Neurology Research International Pub Date : 2018-10-09 eCollection Date: 2018-01-01 DOI:10.1155/2018/3172679

Emily R Rosario, Stephanie E Kaplan, Sepehr Khonsari, Garrett Vazquez, Niyant Solanki, Melanie Lane, Hiriam Brownell, Sheila S Rosenberg

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引用次数: 20

Abstract

Background: While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits.

Objective: To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke.

Methods: Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7). Each subject then received two 4-week periods of HBOT for a total of 40 90-minute treatments over a 12-week period. Subjects completed a battery of assessments and had blood drawn six times over the 9-month total duration of the study.

Results: We found improvements in cognition and executive function as well as physical abilities, specifically, improved gait. Participants reported improved sleep and quality of life following HBOT treatment. We also saw changes in serum levels of biomarkers for inflammation and neural recovery. In the functional domains where improvement was observed following HBOT treatment, the improvements were maintained up to 3 months following the last treatment. However, the physiological biomarkers showed a pattern of more transient changes following HBOT treatment.

Conclusions: Findings from this study support the idea of HBOT as a potential intervention following stroke.

Abstract Image

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高压氧治疗对缺血性脑卒中所致功能障碍的影响。

背景:虽然研究表明高压氧治疗(HBOT)对神经损伤有益处，但对照临床试验尚未能够清楚地定义其益处。目的:探讨HBOT对缺血性脑卒中所致身体和认知功能障碍的影响。方法:采用受试者内设计，在3个月内为所有受试者(n=7)建立当前功能能力基线。每个受试者随后接受两次为期4周的HBOT治疗，在12周的时间内共进行40次90分钟的治疗。受试者完成了一系列评估，并在9个月的研究期间抽血6次。结果:我们发现认知和执行功能以及身体能力都有所改善，特别是步态有所改善。参与者报告了HBOT治疗后睡眠和生活质量的改善。我们还看到了炎症和神经恢复的生物标志物的血清水平的变化。在HBOT治疗后观察到改善的功能领域，这种改善在最后一次治疗后持续了3个月。然而，生理生物标志物显示了HBOT治疗后更短暂的变化模式。结论:本研究结果支持HBOT作为卒中后潜在干预手段的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Research International NEUROSCIENCES-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Neurology Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on diseases of the nervous system, as well as normal neurological functioning. The journal will consider basic, translational, and clinical research, including animal models and clinical trials.

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