Reninoma: a rare cause of curable hypertension.

Korean Journal of Pediatrics Pub Date : 2019-04-01 Epub Date: 2018-10-29 DOI:10.3345/kjp.2018.06926
Ji Hye Kim, Ji Hyun Kim, Myung Hyun Cho, Eujin Park, Hye Sun Hyun, Yo Han Ahn, Hee Gyung Kang, Kyung Chul Moon, Il-Soo Ha, Hae Il Cheong
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引用次数: 7

Abstract

The most common type of refractory hypertension found in children is secondary hypertension, which is a potentially curable disease. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension that is usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures the hypertension of patients with reninoma. The typical clinical presentation of reninoma includes hypokalemia, metabolic alkalosis, and features secondary to the increased activation of the renin-angiotensin system without renal artery stenosis. We report a case of reninoma in a female adolescent with a typical clinical presentation, in which surgical removal of the tumor completely cured hypertension. We discuss here the clinical features, imaging studies, and immunohistochemical examination of the tumor used to establish the diagnosis of reninoma and for the management of the condition.

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肾鞘瘤:一种罕见的可治愈的高血压病因。
在儿童中发现的最常见的顽固性高血压类型是继发性高血压,这是一种潜在可治愈的疾病。肾腺瘤是一种分泌肾素的肾小球旁细胞瘤,是一种罕见的引起严重高血压的原因,通常在青少年和年轻人中被诊断出来。手术切除肿瘤可完全治愈肾鞘瘤患者的高血压。肾鞘瘤的典型临床表现包括低钾血症、代谢性碱中毒,以及继发于肾素-血管紧张素系统激活增加而无肾动脉狭窄的特征。我们报告一例典型的女性青少年肾鞘瘤的临床表现,其中手术切除肿瘤完全治愈高血压。我们在此讨论临床特征,影像学研究和肿瘤的免疫组织化学检查,用于确定肾鞘瘤的诊断和病情的管理。
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来源期刊
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审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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