[The prevalence of human papillomaviruses in patients with colon polyps].

Medycyna doswiadczalna i mikrobiologia Pub Date : 2017-01-01

Beata Mlynarczyk-Bonikowska, Jacek Muszyński, Ksenia Szymanek-Mjchrzak, Bartomiej Ziółowski, Graiyna Mlynarczyk, Magdalena Malejczyk, Lawomir Majewski

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Abstract

Introduction: Potential role of HPV infection in pathogenesis of colon polyps and cancer remains undetermined. The aim of the study was to investigate the prevalence of DNA of HPV- 6, -11, -16 and -18 in the biopsies from colon polyps.

Material and methods: We investigated the biopsies from 24 patients (23 from colon polyps and I from colon cancer) of Department of Gastroenterology Medical University of Warsaw using Real time PCR HPV-6/11. Real-TM (Sacace Biotechnologies) was performed on termocycler Smart Cycler Dx.

Results: We didn't detect oncogenic HPV16 and HPV18 in any of the investigated specimens, HPV-11 was present in 11 patients including all patients with adenoma tubule-villosum. We detect HPV6 in 5 samples from polyps and 1 from colon cancer.

Conclusions: HPV 6 and HPV 11 could play a role in pathogenesis some colon polyps but the final conclusions demand further investigations. Oncogenic HPV 16 and 18 probably don't play any role in colon polyps pathogenesis.

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【人乳头瘤病毒在结肠息肉患者中的流行】。

简介:HPV感染在结肠息肉和结肠癌发病机制中的潜在作用尚未确定。该研究的目的是调查结肠息肉活检中HPV- 6、-11、-16和-18 DNA的流行情况。材料和方法:采用Real time PCR HPV-6/11对华沙医科大学消化内科24例患者(结肠息肉23例，结肠癌1例)的活检组织进行分析。Real-TM (Sacace Biotechnologies)在termocycler Smart Cycler Dx上进行检测。结果:所有样本均未检出致瘤性HPV16和HPV18, 11例患者均检出HPV-11，包括所有小管-绒毛腺瘤患者。我们在5个息肉样本和1个结肠癌样本中检测到HPV6。结论:HPV 6和HPV 11可能在某些结肠息肉的发病机制中起作用，但最终结论有待进一步研究。致瘤性HPV 16和18可能在结肠息肉的发病机制中没有任何作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medycyna doswiadczalna i mikrobiologia

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