Epidemiology of Rotavirus A in Nigeria: Molecular Diversity and Current Insights.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2018-10-01 DOI:10.1155/2018/6513682

Babatunde Olanrewaju Motayo, Adedayo Omotayo Faneye, Johnson Adekunle Adeniji

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引用次数: 10

Abstract

Rotavirus induced acute gastroenteritis AGE has been a major disease burden in Nigeria, since it was first reported in 1985. Prevalence rates have increased with severe public health consequences particularly among children. The vaccine Rotarix® has been introduced and is commercially available in Nigeria. However routine rotavirus vaccination is yet to be introduced into the National Immunization Program. Molecular epidemiology of rotavirus in Nigeria has shown the presence of various genotypes, with genotype G12P[8] being the most recent introduction. There are however gaps in molecular data on rotavirus in Nigeria. We therefore reviewed molecular data on rotavirus isolated in Nigeria and also analyzed VP4 and VP7 genes of Nigerian rotavirus strains in Genbank. We have shown that there is a distinct trend in rotavirus molecular epidemiology in Nigeria, with new genotype introductions occurring after the year 2010. We also observed from our analysis the emergence of genotype G12 Lineage III as a dominant genotype. This information elucidates rotavirus molecular epidemiology in Nigeria and gives insight to the expanding landscape of rotavirus genotypes. We recommend the institution of molecular surveillance country wide, before considering the inclusion of rotavirus vaccination into the National Immunization Program in Nigeria, in other to monitor evolution of divergent or recombinant strains.

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尼日利亚轮状病毒A的流行病学：分子多样性和当前见解。

自1985年首次报道以来，轮状病毒引起的急性胃肠炎一直是尼日利亚的主要疾病负担。患病率上升，对公共卫生造成严重后果，尤其是在儿童中。Rotarix®疫苗已在尼日利亚上市。然而，常规轮状病毒疫苗接种尚未纳入国家免疫计划。尼日利亚轮状病毒的分子流行病学显示存在各种基因型，基因型G12P[8]是最新引入的。然而，尼日利亚轮状病毒的分子数据存在空白。因此，我们回顾了在尼日利亚分离的轮状病毒的分子数据，并在Genbank中分析了尼日利亚轮状病毒株的VP4和VP7基因。我们已经表明，尼日利亚的轮状病毒分子流行病学有一个明显的趋势，2010年之后出现了新的基因型引入。我们还从我们的分析中观察到基因型G12谱系III作为显性基因型的出现。这一信息阐明了尼日利亚的轮状病毒分子流行病学，并深入了解了轮状病毒基因型的不断扩大。我们建议在考虑将轮状病毒疫苗纳入尼日利亚国家免疫计划之前，在全国范围内进行分子监测，以监测变异株或重组株的进化。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.