Liliya M Yamaleyeva, K Bridget Brosnihan, Lane M Smith, Yao Sun
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引用次数: 0
Abstract
Placental oxygenation varies throughout pregnancy. The detection of early changes in placental oxygenation as pregnancy progresses is important for early identification of preeclampsia or other complications. This invited commentary discusses a recent preclinical study on the application of 3-dimensional photoacoustic imaging (PAI) for assessment of regional variations in placental oxygenation and longitudinal analysis of differences in placental oxygenation throughout normal pregnancy and pregnancy associated with hypertension or placental insufficiency in mice. Three-dimensional PAI more accurately reflects oxygen saturation, hemoglobin concentrations, and changes in oxygen saturation in whole placenta compared to 2-dimensional imaging. These studies suggest that PAI is a sensitive tool to detect different levels of oxygen saturation in the placental and fetal vasculature in pathologic and normal pregnancy in mice.
胎盘氧合在整个孕期都会发生变化。随着妊娠的进展，检测胎盘氧合的早期变化对于早期识别子痫前期或其他并发症非常重要。这篇特邀评论讨论了最近的一项临床前研究，该研究应用三维光声成像（PAI）评估胎盘氧合的区域变化，并纵向分析正常妊娠和妊娠合并高血压或胎盘功能不全小鼠胎盘氧合的差异。与二维成像相比，三维 PAI 能更准确地反映整个胎盘的血氧饱和度、血红蛋白浓度和血氧饱和度的变化。这些研究表明，PAI 是检测小鼠病理妊娠和正常妊娠中胎盘和胎儿血管中不同氧饱和度水平的灵敏工具。
Molecular ImagingBiochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍：
Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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