[THE CLINICAL COURSE OF HEPATITIS C IN CHILDREN WITH DIFFERENT VARIANTS OF THE GENE POLYMORPHISM IL28B].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

I A Matinyan, T B Sentsova, I V Vorozhko, O O Chernyak, T V Strokova, M M G Gapparov

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Abstract

Aim of investigation: The aim of the research is to study the clinical course of hepatitis C in children with different variants of the gene polymorphism of IL-28B.

Materials and methods: We observed 94 children (46 girls and 48 boys) with chronic hepatitis C (CHC) in age from 3 to 17 years (mean age 10 years). There were significant differences in the distribution of allele frequencies in children with chronic hepatitis C and in the population. In children with chronic hepatitis C significantly increased the incidence of the T allele at the locus of the gene IL-28B rs12979860 C>T, which makes it possible to consider it as a predictor of antiviral therapy ineffective.

Results: When analyzing the frequency of occurrence of a polymorphic variant T>G [rs8099917] IL-28B gene in children with chronic hepatitis C and healthy children revealed no differences in the distribution of alleles.

Conclusion: Personalized approach to the appointment of HCV antiviral therapy in children is to carry out genetic studies to determine on the basis of predictive features of the course of HCV in children during the treatment.

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[il28b基因多态性不同变体儿童的丙型肝炎临床病程]。

研究目的研究的目的是研究IL-28B基因多态性不同变体儿童的丙型肝炎临床病程：我们观察了 94 名年龄在 3 至 17 岁（平均年龄 10 岁）的慢性丙型肝炎（CHC）患儿（46 名女孩和 48 名男孩）。慢性丙型肝炎患儿的等位基因频率分布与人群中的等位基因频率分布存在明显差异。在慢性丙型肝炎儿童中，基因 IL-28B rs12979860 C>T 位点上 T 等位基因的发生率明显增加，因此可以将其视为抗病毒治疗无效的预测因子：结果：在分析慢性丙型肝炎患儿和健康儿童IL-28B基因多态变异T>G [rs8099917]的发生频率时，发现等位基因的分布没有差异：儿童 HCV 抗病毒治疗的个性化方法是开展基因研究，在此基础上确定治疗期间儿童 HCV 病程的预测特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology

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