[GENETIC PREDISPOSITION TO DEVELOPMENT OF TOXIC HEPATITIS].

Abstract

Aim: The aim of this study was to investigate the frequency of polymorphic variants of genes CYP2E1 and GSTA1 in patients with pathology of the hepatobiliary system (PHS) and healthy individuals in the Republic of Bashkortostan, as well as an analysis of possible associations of genotypes of this gene with the development of PHS.

Materials and methods: There were examined 81 patients with pathology of the hepatobiliary system. Was studied association analysis of polymorphic loci of genes CYP2E1 and GSTA1.

Results: The study demonstrated that a marker of risk of developing the disease is AA genotype (OR = 2,09; 95% CI 1,07-4,10) polymorphic locus gene rs3957357 GSTA1.