Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities†

IF 10.6 1区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Senhua Chen , Runlin Cai , Zhaoming Liu , Hui Cui , Zhigang She
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引用次数: 45

Abstract

Covering 1989 to 2020

The mangrove forests are a complex ecosystem occurring at tropical and subtropical intertidal estuarine zones and nourish a diverse group of microorganisms including fungi, actinomycetes, bacteria, cyanobacteria, algae, and protozoa. Among the mangrove microbial community, mangrove associated fungi, as the second-largest ecological group of the marine fungi, not only play an essential role in creating and maintaining this biosphere but also represent a rich source of structurally unique and diverse bioactive secondary metabolites, attracting significant attention of organic chemists and pharmacologists. This review summarizes the discovery relating to the source and characteristics of metabolic products isolated from mangrove-associated fungi over the past thirty years (1989–2020). Its emphasis included 1387 new metabolites from 451 papers, focusing on bioactivity and the unique chemical diversity of these natural products.

Abstract Image

红树林相关真菌次生代谢物:来源、化学和生物活性
红树林是一个复杂的生态系统,分布在热带和亚热带潮间带河口地带,滋养着多种微生物,包括真菌、放线菌、细菌、蓝藻、藻类和原生动物。在红树林微生物群落中,红树林伴生真菌作为海洋真菌的第二大生态类群,不仅对红树林生物圈的形成和维持起着至关重要的作用,而且具有丰富的结构独特和多样的生物活性次生代谢产物,引起了有机化学家和药理学家的极大关注。本文综述了近30年来(1989-2020年)从红树林相关真菌中分离的代谢产物的来源和特征。其重点包括来自451篇论文的1387种新的代谢物,重点关注这些天然产物的生物活性和独特的化学多样性。
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来源期刊
Natural Product Reports
Natural Product Reports 化学-生化与分子生物学
CiteScore
21.20
自引率
3.40%
发文量
127
审稿时长
1.7 months
期刊介绍: Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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