A case-control study on the association of abdominal obesity and hypercholesterolemia with the risk of colorectal cancer.

Q1 Environmental Science

Journal of Carcinogenesis Pub Date : 2018-09-25 eCollection Date: 2018-01-01 DOI:10.4103/jcar.JCar_2_18

Vaidehi Ulaganathan, Mirnalini Kandiah, Zalilah Mohd Shariff

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引用次数: 19

Abstract

Background: Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases.

Objective: The objective of this study was to determine the relationship between obesity and blood lipids with a risk of colorectal cancer (CRC).

Methodology: Histologically confirmed CRC patients from five local hospitals were matched with cancer-free controls for age, gender, and ethnicity (n = 140: 280). The study participants underwent physical assessment for the presence of obesity and 10 mL of fasting blood was drawn for blood lipid analysis.

Results: In this study, abdominal obesity significantly doubled the risk of CRC (adjusted odds ratio [AOR] =1.69, 95% confidence interval [CI] = 1-2.83). Hypercholesterolemia and low high-density lipoprotein cholesterol (HDL) increased the risk of CRC more than twofolds (AOR = 2.6, 95% CI = 1.7-3.9 and AOR = 3.8, 95% CI = 2.3-6.3, respectively). Abdominal obesity and hypercholesterolemia synergically doubled the risk of CRC (AOR = 2.0, 95% CI = 1-4). Low-HDL has shown no synergic association with other dyslipidemic states with an increased CRC risk.

Conclusion: Improving abdominal obesity, hypercholesterolemia, and low HDL may be a clinically relevant strategy to reduce the risk of CRC among Malaysians.

Abstract Image

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腹部肥胖和高胆固醇血症与结直肠癌风险相关性的病例对照研究。

背景:肥胖经常与血脂异常状态和各种慢性疾病的风险相关。目的:本研究的目的是确定肥胖和血脂与结直肠癌(CRC)风险之间的关系。方法:将来自五家当地医院的组织学证实的结直肠癌患者与无癌对照者按年龄、性别和种族进行匹配(n = 140: 280)。研究参与者接受了肥胖的身体评估，并抽取了10毫升空腹血进行血脂分析。结果:在本研究中，腹部肥胖使结直肠癌的风险显著增加一倍(调整优势比[AOR] =1.69, 95%可信区间[CI] = 1-2.83)。高胆固醇血症和低高密度脂蛋白胆固醇(HDL)使结直肠癌的风险增加两倍以上(AOR = 2.6, 95% CI = 1.7-3.9和AOR = 3.8, 95% CI = 2.3-6.3)。腹部肥胖和高胆固醇血症协同作用使CRC的风险增加一倍(AOR = 2.0, 95% CI = 1-4)。低hdl与其他血脂异常状态与CRC风险增加没有协同关联。结论:改善腹部肥胖、高胆固醇血症和低HDL可能是降低马来西亚人结直肠癌风险的临床相关策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Carcinogenesis Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

7.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. Primary areas of interest to the journal include: physical and chemical carcinogenesis and mutagenesis; processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the mechanism of action of carcinogens and modulating agents; epidemiological studies; and, the formation, detection, identification, and quantification of environmental carcinogens. Manuscripts that contribute to the understanding of cancer prevention are especially encouraged for submission