Normothermic ex vivo liver perfusion: platform for liver graft assessment and therapeutic modification.

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2018-01-01 Epub Date: 2018-10-05 DOI:10.1080/15476278.2018.1517564

Corey Eymard, James Markmann

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引用次数: 1

Abstract

Liver transplantation as a treatment for end stage liver failure remains limited in the United States by the number and quality of donor allografts. Static cold storage, the current standard of care for organ storage prior to transplantation, offers no method for assessment or therapeutic modification. Cold ischemia and its attendant hypoxia deplete cellular adenosine triphosphate (ATP) stores, promote cellular damage, and degrade overall organ quality. Normothermic ex vivo liver perfusion (NEVLP) offers the potential for assessment of allograft function and restoration of intracellular energy stores prior to transplantation. A completed phase III randomized trial demonstrated livers undergoing NEVLP prior to transplantation demonstrate superior early graft function and less early graft dysfunction. NEVLP offers a platform for modification of the allograft via the application of defatting or therapeutic cocktails, missense RNA technology, or gene editing modalities. The wide versatility of NEVLP appears to be a promising tool to expand the current pool of transplantable liver allografts.

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常温离体肝灌注:肝移植评估和治疗修改的平台。

肝移植作为终末期肝衰竭的一种治疗方法，在美国由于同种异体供体移植的数量和质量仍然有限。静态冷库是目前移植前器官储存的标准，没有提供评估或治疗修改的方法。冷缺血及其伴随的缺氧会耗尽细胞三磷酸腺苷(ATP)的储存，促进细胞损伤，并降低整个器官的质量。常温离体肝灌注(NEVLP)为移植前评估同种异体移植物功能和恢复细胞内能量储存提供了可能。一项完成的III期随机试验表明，移植前接受NEVLP的肝脏表现出更好的早期移植物功能和更少的早期移植物功能障碍。NEVLP提供了一个通过脱脂或治疗鸡尾酒、错义RNA技术或基因编辑方式对同种异体移植物进行修饰的平台。NEVLP的广泛通用性似乎是一个有前途的工具，以扩大目前的可移植同种异体肝脏移植池。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.

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