{"title":"[Efficiency of Cell Transplantation in Repair of Mouse Liver Damage].","authors":"E S Korobko, E A Suprunenko, A V Vasil’ev","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effectiveness of two transplantation methods of human hepatocellular carcinoma cells HepG2\nand allogeneic mesenchymal stromal cells of adipose tissue (AT MSCs) into mice was compared in order to\nselect the most effective for liver damage repair. Considerable advantage of cell transplantation into the spleen\ncompared with intraperitoneal administration was shown. It is found that, under similar conditions of transplantation,\nAT MSCs are detected in liver tissue in smaller quantities than human hepatocellular carcinoma\ncells HepG2; differences in cell localization of these types of cells in the liver are revealed. A tendency to\ndecrease in the degree of fibrotic changes in liver tissue after transplantation of AT MSCs and to a greater\nextent after transplantation of AT MSCs, pretreated with interleukin-6, was traced.</p>","PeriodicalId":19673,"journal":{"name":"Ontogenez","volume":"48 1","pages":"55-62"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ontogenez","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The effectiveness of two transplantation methods of human hepatocellular carcinoma cells HepG2
and allogeneic mesenchymal stromal cells of adipose tissue (AT MSCs) into mice was compared in order to
select the most effective for liver damage repair. Considerable advantage of cell transplantation into the spleen
compared with intraperitoneal administration was shown. It is found that, under similar conditions of transplantation,
AT MSCs are detected in liver tissue in smaller quantities than human hepatocellular carcinoma
cells HepG2; differences in cell localization of these types of cells in the liver are revealed. A tendency to
decrease in the degree of fibrotic changes in liver tissue after transplantation of AT MSCs and to a greater
extent after transplantation of AT MSCs, pretreated with interleukin-6, was traced.