Black, White, and Gray: Macrophages in Skin Repair and Disease.

Q1 Medicine
Current Pathobiology Reports Pub Date : 2017-12-01 Epub Date: 2017-10-14 DOI:10.1007/s40139-017-0152-8
Melanie Rodrigues, Geoffrey Gurtner
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引用次数: 0

Abstract

Purpose of review: Macrophages alter their responses during the temporal stages of wound healing. During the inflammatory phase macrophages perform phagocytosis. During neovascularization macrophages activate angiogenesis. In the proliferation phase of wound healing, macrophages deposit extracellular matrix and during wound resolution macrophages phagocytize excessive cellular components. This review addresses how these changing phenotypes affect skin repair and disease.

Recent findings: Macrophages can determine the outcome of repair and can shift the normal wound healing response into fibrosis or chronic wounds. Emerging single cell technologies for the first time provide us with tools to uncover macrophage origin, heterogeneity and function.

Summary: Macrophages may exist as one population where all cells alter their phenotype in response to signals from the microenvironment. Alternatively, macrophages may exist as distinct subsets that can control wound outcomes. A clarified understanding will strengthen our knowledge of skin biology and aid in the development of wound healing therapies.

Abstract Image

Abstract Image

黑、白、灰:皮肤修复和疾病中的巨噬细胞》(Black, White, and Gray: Macrophages in Skin Repair and Disease)。
综述的目的:巨噬细胞在伤口愈合的不同阶段会改变其反应。在炎症阶段,巨噬细胞进行吞噬。在新生血管形成阶段,巨噬细胞激活血管生成。在伤口愈合的增殖阶段,巨噬细胞沉积细胞外基质;在伤口愈合过程中,巨噬细胞吞噬过多的细胞成分。本综述探讨了这些不断变化的表型如何影响皮肤修复和疾病:巨噬细胞能决定修复的结果,并能将正常的伤口愈合反应转变为纤维化或慢性伤口。新兴的单细胞技术首次为我们提供了揭示巨噬细胞起源、异质性和功能的工具。摘要:巨噬细胞可能作为一个群体存在,在这个群体中,所有细胞都会根据来自微环境的信号改变其表型。或者,巨噬细胞可能作为不同的亚群存在,它们可以控制伤口的结果。澄清这一认识将加强我们对皮肤生物学的了解,并有助于伤口愈合疗法的开发。
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来源期刊
Current Pathobiology Reports
Current Pathobiology Reports Medicine-Pathology and Forensic Medicine
CiteScore
6.40
自引率
0.00%
发文量
3
期刊介绍: This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.
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