{"title":"[Role of Mechano-Dependent Cell Movements in the Establishment of Spatial Organization of Axial Rudiments in Xenopus laevis Embryos].","authors":"D V Bredov, A U Evstifeeva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Trajectories of individual cell movements and patterns of differentiation in the axial rudiments in\nsuprablastoporal areas (SBA) in whole embryos of Xenopus laevis artificially stretched in the transverse direction\nup to 120–200% from the initial length at the early gastrula stage were mapped. We observed the impairment\nof anisotropic cell movements of longitudinal stretching and latero-medial convergence inherent for\nSBA. Axial rudiments occurred in all cases, but their location was completely impaired and dramatically different\nfrom the normal topology for moderate (120–140%) stretching. Stronger stretching caused a partial\nordering of the whole axial complex and its reorientation toward stretching. We concluded that induction factors\ndetermine short-range order in their arrangement in SBA, whereas anisotropic cell movements in any\ndirection are needed for long-range order. Moderate transverse stretching destroys normally oriented anisotropy,\nbut it is not enough for establishment of the anisotropy oriented perpendicular to the normal. This\nexplains the disorder at light stretching. The main conclusion of this study is that anisotropic tensions of\nembryonic tissues play role of long-range order parameters of cell differentiation.</p>","PeriodicalId":19673,"journal":{"name":"Ontogenez","volume":"48 1","pages":"21-7"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ontogenez","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Trajectories of individual cell movements and patterns of differentiation in the axial rudiments in
suprablastoporal areas (SBA) in whole embryos of Xenopus laevis artificially stretched in the transverse direction
up to 120–200% from the initial length at the early gastrula stage were mapped. We observed the impairment
of anisotropic cell movements of longitudinal stretching and latero-medial convergence inherent for
SBA. Axial rudiments occurred in all cases, but their location was completely impaired and dramatically different
from the normal topology for moderate (120–140%) stretching. Stronger stretching caused a partial
ordering of the whole axial complex and its reorientation toward stretching. We concluded that induction factors
determine short-range order in their arrangement in SBA, whereas anisotropic cell movements in any
direction are needed for long-range order. Moderate transverse stretching destroys normally oriented anisotropy,
but it is not enough for establishment of the anisotropy oriented perpendicular to the normal. This
explains the disorder at light stretching. The main conclusion of this study is that anisotropic tensions of
embryonic tissues play role of long-range order parameters of cell differentiation.