[Role of Mechano-Dependent Cell Movements in the Establishment of Spatial Organization of Axial Rudiments in Xenopus laevis Embryos].

Ontogenez Pub Date : 2017-01-01
D V Bredov, A U Evstifeeva
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Abstract

Trajectories of individual cell movements and patterns of differentiation in the axial rudiments in suprablastoporal areas (SBA) in whole embryos of Xenopus laevis artificially stretched in the transverse direction up to 120–200% from the initial length at the early gastrula stage were mapped. We observed the impairment of anisotropic cell movements of longitudinal stretching and latero-medial convergence inherent for SBA. Axial rudiments occurred in all cases, but their location was completely impaired and dramatically different from the normal topology for moderate (120–140%) stretching. Stronger stretching caused a partial ordering of the whole axial complex and its reorientation toward stretching. We concluded that induction factors determine short-range order in their arrangement in SBA, whereas anisotropic cell movements in any direction are needed for long-range order. Moderate transverse stretching destroys normally oriented anisotropy, but it is not enough for establishment of the anisotropy oriented perpendicular to the normal. This explains the disorder at light stretching. The main conclusion of this study is that anisotropic tensions of embryonic tissues play role of long-range order parameters of cell differentiation.

[机械依赖细胞运动在非洲爪蟾胚胎轴向雏形空间组织建立中的作用]。
绘制了非洲爪蟾(Xenopus laevis)全胚在原肠期早期横向人工拉伸至初始长度120 ~ 200%的轴向芽胞区(SBA)中单个细胞的运动轨迹和分化模式。我们观察到各向异性细胞运动的纵向拉伸和前后向收敛固有的forSBA损伤。所有病例均出现轴向雏形,但在中度(120-140%)拉伸时,其位置完全受损,与正常拓扑结构显著不同。较强的拉伸导致整个轴向络合物部分有序并向拉伸方向重新定向。我们得出的结论是,诱导因子决定了它们在SBA中的短期排列顺序,而细胞在任何方向的各向异性运动则需要长期排列顺序。适度的横向拉伸破坏了正向取向的各向异性,但不足以建立垂直于法线取向的各向异性。这就解释了光拉伸的无序性。本研究的主要结论是胚胎组织的各向异性张力在细胞分化的远程序参数中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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