Long-Term Effects of Intense Pulsed Light Combined with Meibomian Gland Expression in the Treatment of Meibomian Gland Dysfunction.

Q2 Medicine

Photomedicine and laser surgery Pub Date : 2018-10-01 Epub Date: 2018-09-22 DOI:10.1089/pho.2018.4499

Bei Rong, Yun Tang, Ruixing Liu, Ping Tu, Jing Qiao, Wenjing Song, Xiaoming Yan

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引用次数: 54

Abstract

Objective: To evaluate the long-term effects of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in the treatment of meibomian gland dysfunction (MGD).

Background: Although IPL has been proven to be effective in the treatment of MGD, any report regarding its long-term efficacy is unavailable by now.

Methods: The randomly selected study eye received a series of three IPL treatments that were applied directly on eyelids with an interval of 4 weeks (treatment energy, 14-16 J/cm²). The control eye received three sham IPL treatments (0 J/cm²). MGX was performed on both eyes. Meibomian gland yielding secretion score (MGYSS) and tear film break-up time (TBUT) were evaluated at baseline and at 1, 3, 6, and 9 months after treatments.

Results: In the study eyes, MGYSS of both the upper and lower eyelids and TBUT improved at 1, 3, 6 months after treatments (p < 0.01). MGYSS in lower eyelids continued to improve at 9 months (p < 0.05). The changes in MGYSS and TBUT after treatment were larger in the study eyes than in the control eyes at 1, 3, 6 months (p < 0.01), but no difference at 9 months (p > 0.05). The percentage improvement in the MGYSS of lower eyelids after treatment was higher than that of upper eyelids.

Conclusions: Three consecutive IPL treatments combined with MGX improved MG secretion function and TBUT by 6 months after treatment in MGD patients. The improvement in MG secretion function was greater in the lower eyelid than in the upper eyelid.

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强脉冲光联合睑板腺表达治疗睑板腺功能障碍的远期效果。

目的:探讨强脉冲光(IPL)联合睑板腺表达(MGX)治疗睑板腺功能障碍(MGD)的远期疗效。背景:虽然IPL已被证明对MGD的治疗有效，但目前尚无关于其长期疗效的报道。方法:随机选择研究眼，连续3次IPL治疗，每次治疗间隔4周(治疗能量14-16 J/cm2)。对照眼接受3次假IPL治疗(0 J/cm2)。双眼行MGX手术。分别于基线及治疗后1、3、6、9个月评估睑板腺分泌评分(MGYSS)和泪膜破裂时间(TBUT)。结果:研究眼治疗后1、3、6个月，上、下眼睑MGYSS及TBUT均有改善(p < 0.05)。治疗后下眼睑的MGYSS改善率高于上眼睑。结论:连续3次IPL联合MGX治疗可改善MGD患者6个月后的MG分泌功能和TBUT。MG分泌功能的改善下眼睑明显大于上眼睑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photomedicine and laser surgery 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Photobiomodulation, Photomedicine, and Laser Surgery (formerly Photomedicine and Laser Surgery) is the essential journal for cutting-edge advances and research in phototherapy, low-level laser therapy (LLLT), and laser medicine and surgery. The Journal delivers basic and clinical findings and procedures to improve the knowledge and application of these techniques in medicine.