Targeting kinases with precision.

Molecular & cellular oncology Pub Date : 2018-04-11 eCollection Date: 2018-01-01 DOI:10.1080/23723556.2018.1435183
Alexandra K Gardino, Erica K Evans, Joseph L Kim, Natasja Brooijmans, Brian L Hodous, Beni Wolf, Christoph Lengauer
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引用次数: 9

Abstract

Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yield potent, highly selective drugs. With optimized drugs in hand, physicians could apply the principles of personalized medicine with an increasing number of options to treat patients with improved precision according to their tumor's molecular genotype.

Abstract Image

精确定位激酶。
癌症基因组学和机制研究表明,单一激酶内的异质突变可导致多种激活机制。挑战在于将这些见解与量身定制的药物发现策略相匹配,以产生有效的、高选择性的药物。有了优化的药物在手,医生可以应用个性化医疗的原则,根据肿瘤的分子基因型,有越来越多的选择来提高治疗患者的精度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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