CHMP4C: A novel regulator of the mitotic spindle checkpoint.

Molecular & cellular oncology Pub Date : 2018-04-11 eCollection Date: 2018-01-01 DOI:10.1080/23723556.2018.1445944
Eleni Petsalaki, George Zachos
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引用次数: 7

Abstract

The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery, protects human cells against chromosome missegregation by promoting localisation of the ROD-ZW10-ZWILCH (RZZ) spindle checkpoint complex to unattached kinetochores.

Abstract Image

CHMP4C:一种新的有丝分裂纺锤体检查点调节因子。
有丝分裂纺锤体检查点延迟后期的开始,直到所有染色体都获得稳定的着丝点-微管附着。在这里,我们讨论了最近的研究结果,表明CHMP4C是运输(ESCRT)机制所需的内体分选复合体的一个组成部分,通过促进ROD-ZW10-ZWILCH (RZZ)纺锤体检查点复合体定位到未附着的着丝点来保护人类细胞免受染色体错误分离。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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