{"title":"Dual-view acoustic-resolution photoacoustic microscopy with enhanced resolution isotropy.","authors":"Emelina Vienneau, Wei Liu, Junjie Yao","doi":"10.1364/OL.43.004413","DOIUrl":null,"url":null,"abstract":"<p><p>Acoustic-resolution photoacoustic microscopy (AR-PAM) can provide penetration depths beyond the optical diffusion limit, but its lateral resolution is typically much worse than its axial resolution, resulting in a low-resolution isotropy. We herein present a dual-view AR-PAM (DV-AR-PAM) system that exploits two orthogonally arranged focused ultrasonic transducers. Taking advantage of their complementary acoustic detecting profiles, DV-AR-PAM allows the fusion of the dual-view signals, resulting in an enhancement in the resolution isotropy from 29% to 95% within one imaging plane, as demonstrated by simulation results on densely packed particles and experimental results on a single carbon fiber. The application of this method in vivo revealed distinct microvasculature structures in mouse skin that were previously indistinguishable with single-view detection, demonstrating the potential of DV-AR-PAM for vascular and neurological studies.</p>","PeriodicalId":19540,"journal":{"name":"Optics letters","volume":"43 18","pages":"4413-4416"},"PeriodicalIF":3.3000,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1364/OL.43.004413","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Optics letters","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1364/OL.43.004413","RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 13
Abstract
Acoustic-resolution photoacoustic microscopy (AR-PAM) can provide penetration depths beyond the optical diffusion limit, but its lateral resolution is typically much worse than its axial resolution, resulting in a low-resolution isotropy. We herein present a dual-view AR-PAM (DV-AR-PAM) system that exploits two orthogonally arranged focused ultrasonic transducers. Taking advantage of their complementary acoustic detecting profiles, DV-AR-PAM allows the fusion of the dual-view signals, resulting in an enhancement in the resolution isotropy from 29% to 95% within one imaging plane, as demonstrated by simulation results on densely packed particles and experimental results on a single carbon fiber. The application of this method in vivo revealed distinct microvasculature structures in mouse skin that were previously indistinguishable with single-view detection, demonstrating the potential of DV-AR-PAM for vascular and neurological studies.
期刊介绍：
The Optical Society (OSA) publishes high-quality, peer-reviewed articles in its portfolio of journals, which serve the full breadth of the optics and photonics community.
Optics Letters offers rapid dissemination of new results in all areas of optics with short, original, peer-reviewed communications. Optics Letters covers the latest research in optical science, including optical measurements, optical components and devices, atmospheric optics, biomedical optics, Fourier optics, integrated optics, optical processing, optoelectronics, lasers, nonlinear optics, optical storage and holography, optical coherence, polarization, quantum electronics, ultrafast optical phenomena, photonic crystals, and fiber optics. Criteria used in determining acceptability of contributions include newsworthiness to a substantial part of the optics community and the effect of rapid publication on the research of others. This journal, published twice each month, is where readers look for the latest discoveries in optics.
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