Nano-Based Therapy for Treatment of Skin Cancer.

Q3 Medicine
Sadaf J Gilani, Mohammed A Jahangir, Chandrakala, Md Rizwanullah, Mohamad Taleuzzaman, Mohammad S Shahab, Kashif Shakeel, Mohd Aqil, Syed S Imam
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引用次数: 9

Abstract

Background: According to the World Health Organization, skin cancer is the most common malignancy for the population. Conventional skin cancer treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties. There are a number of patents on topical nano formulation like nanoparticle (US9757453; US9457041), liposomes (US2018177726 (A1), has been covered in this review in the treatment of skin cancer.

Methods: Encapsulated drugs are advantageous due to such properties as high stability, better bioavailability, controlled drug release, a long blood circulation time, selective organ or tissue distribution, a lower total required dose, and minimal toxic side effects. Today, researchers are constantly developing new formulations to meet unmet needs in the delivery of therapeutic agents for cancer therapy and diagnosis, respectively.

Results: Of particular interest here are lipid-based nanoformulations that are formulated from varieties of lipid and other chemical components that act collectively to overcome biological barriers, in order to preferentially accumulate in or around disease-target cells for the functional delivery of therapeutic agents. The article deals with the recent development of nano-sized topical lipid formulation approaches to treat skin cancer.

Conclusion: We focus especially on the topical lipid formulation approaches combined with chemotherapy, a field which specialises in target specificity, drug release control, and realtime monitoring with the goal being to diminish unwanted side effects and their severity, achieving a cheaper treatment and a generally more efficient chemotherapy.

纳米疗法治疗皮肤癌。
背景:根据世界卫生组织,皮肤癌是人类最常见的恶性肿瘤。传统的皮肤癌治疗包括手术和化疗,但许多化疗药物使用的不良性质。有多项局部纳米制剂专利,如nanoparticle (US9757453;US9457041)、脂质体(US2018177726 (A1))在皮肤癌治疗中的应用已在本综述中得到报道。方法:囊化药物具有稳定性高、生物利用度好、药物释放控制、血液循环时间长、器官或组织分布有选择性、总需要量小、毒副作用小等优点。今天,研究人员正在不断开发新的配方,以满足未满足的需求,分别为癌症治疗和诊断提供治疗剂。结果:这里特别感兴趣的是基于脂质的纳米制剂,这些纳米制剂由各种脂质和其他化学成分配制而成,这些化学成分共同作用以克服生物屏障,以便优先积聚在疾病靶细胞内或周围,以实现治疗剂的功能递送。本文讨论了纳米局部脂质制剂治疗皮肤癌的最新进展。结论:我们特别关注局部脂质制剂方法与化疗相结合,这是一个专注于靶点特异性,药物释放控制和实时监测的领域,目标是减少不必要的副作用及其严重程度,实现更便宜的治疗和更有效的化疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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