Comparative Evaluation of Recombinant Human Bone Morphogenetic Protein-2/Hydroxyapatite and Bovine Bone for New Bone Formation in Alveolar Ridge Preservation.

3区医学 Q1 Dentistry

Implant Dentistry Pub Date : 2018-12-01 DOI:10.1097/ID.0000000000000814

Jae-Yong Shim, Youngkyun Lee, Jae-Hong Lim, Myoung-Uk Jin, Jae-Mok Lee, Jo-Young Suh, Yong-Gun Kim

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引用次数: 19

Abstract

Purpose: Hydroxyapatite treated with recombinant human bone morphogenetic protein-2/Hydroxyapatite (rhBMP-2/HA) or bovine bone was applied on extraction sockets for alveolar ridge preservation, and the results were compared with respect to clinical and histological bone formation.

Materials and methods: This was a prospective, randomized controlled clinical trial performed on 20 implant placement sites (10 in the experimental and 10 in the control group). rhBMP-2/HA was applied on extraction sockets in the experimental group and bovine bone on those of the control group. The bone at the corresponding sites was biopsied 3 months later, and clinical, histological, and histomorphometric analyses were performed.

Results: The alveolar bone height was well preserved in both groups with relatively less change in width in the experimental group compared with the control group. The percentage of new bone was 25.37% ± 17.23% in the experimental group and 6.13% ± 4.32% in the control group; the difference was statistically significant.

Conclusions: The alveolar ridge was preserved clinically and histologically in both groups. rhBMP-2/HA resulted in greater new bone formation than bovine bone 3 months after the surgery.

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重组人骨形态发生蛋白-2/羟基磷灰石与牛骨在牙槽嵴保存中形成新骨的比较评价。

目的:将重组人骨形态发生蛋白-2/羟基磷灰石(rhBMP-2/HA)处理的羟基磷灰石或牛骨分别应用于拔牙槽座保存牙槽嵴，比较临床和组织学骨形成的结果。材料和方法:这是一项前瞻性，随机对照临床试验，在20个种植体放置点进行(实验组10个，对照组10个)。实验组拔牙槽部采用rhBMP-2/HA，对照组拔牙槽部采用牛骨。3个月后对相应部位的骨进行活检，并进行临床、组织学和组织形态计量学分析。结果:两组牙槽骨高度均保持良好，实验组牙槽骨宽度变化较对照组小。实验组新生骨率为25.37%±17.23%，对照组为6.13%±4.32%;差异有统计学意义。结论:两组牙槽嵴在临床和组织学上均得到保留。术后3个月，rhBMP-2/HA比牛骨形成更多的新骨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Implant Dentistry 医学-牙科与口腔外科

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cessation. Implant Dentistry, an interdisciplinary forum for general practitioners, specialists, educators, and researchers, publishes relevant clinical, educational, and research articles that document current concepts of oral implantology in sections on biomaterials, clinical reports, oral and maxillofacial surgery, oral pathology, periodontics, prosthodontics, and research. The journal includes guest editorials, letters to the editor, book reviews, abstracts of current literature, and news of sponsoring societies.