Clinical role of serum Copeptin in acute coronary syndrome

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Egyptian Heart Journal Pub Date : 2018-09-01 DOI:10.1016/j.ehj.2018.04.008

Manal Abd El Baky Mahmoud , Menat Allah Ali Shaaban , Ali Ali Ramzy

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引用次数: 10

Abstract

Objective

To assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period.

Subjects and methods

This study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in addition to 10 subjects serving as a healthy control group. Blood samples were collected for determination of CK-MB, cTnI and Copeptin. These were measured twice (in patients’ group); at 3 h and then at 6–9 h from admission time.

Results

The first sample revealed a non-significant difference between UA group and AMI group as regards CKMB and troponin, however, high significant difference was found as regards Copeptin (Z = 5.29, P < 0.001). Moreover, ROC curve analysis of serum Copeptin for discriminating AMI group from UA group in the first sample showed diagnostic sensitivity and specificity of 100%.

In conclusion

Determination of copeptin in early diagnosis of AMI has diagnostic value being superior to a conventional cTn-I within the first three hours after acute chest pain.

Abstract Image

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血清Copeptin在急性冠脉综合征中的临床作用

目的探讨Copeptin在肌钙蛋白盲期对急性心肌梗死的诊断价值。对象与方法本研究选取了40例因胸痛就诊于急诊科且高度怀疑为急性心脏缺血的患者，另外10例作为健康对照组。取血检测CK-MB、cTnI和Copeptin。这些测量了两次(在患者组);入院后3小时和6-9小时。结果UA组与AMI组CKMB、肌钙蛋白差异无统计学意义，而Copeptin差异有统计学意义(Z = 5.29,P < 0.001)。第一个样本血清Copeptin用于区分AMI组和UA组的ROC曲线分析，诊断敏感性和特异性均为100%。结论在急性胸痛后3小时内检测copeptin对AMI早期诊断的诊断价值优于常规ctn - 1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Egyptian Heart Journal CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： The Egyptian Heart Journal is the official journal of the Egyptian Society of Cardiology. It is an international journal that publishes peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies and translational investigations. The journal publishes research, review articles, case reports and commentary articles, as well as editorials interpreting and commenting on the research presented. In addition, it provides a forum for the exchange of information on all aspects of cardiovascular medicine, including educational issues.