[Expression of Egr-1, Nab2 and Cav-1 and its relationship with scar hyperplasia].

中华整形外科杂志 Pub Date : 2016-11-01

Zixian Chen, Guoqian Yin, Xinyuan Pan, Siding Lu, Shenghua Tang, Qinxi Wei, Jiangying Zhu

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Abstract

Objective To investigate the expression of early growth response protein 1 (Egr-1),NGFI-A binding protein 2 (Nab2) and caveolin 1 (Cav-1) in normal skin,flat-cicatrix and hypertrophic scar,and explore its role in the formation of hypertrophic scar.Methods The expression of Egr-1,Nab2 and Cav-1 protein in 9 normal skin tissues,8 flat-cicatrix tissues and 9 hypertrophic scar tissues were examined with immunohistochemistry SP method and were analyzed statistically.Results The expression of Egr-1 in epidermal cells of hypertrophic scar was significantly higher than that in normal skin and flat scar tissue.The expression of Egr-1 increased in the course of scar proliferation.The distribution patterns of Nab2 were different from Egr-1.The expression of Egr-1 was increased,while expression of Nab2 was decreased.The expression of Cav-1 in normal skin and flat-cicatrix was significantly higher than that in hypertrophic scar.Conclusions The expression of Egr-1,Nab2 and Cav-1 is closely related to the formation of hypertrophic scar,and the up-regulated expression of Egr-1 and the deficient expression of Nab2 and Cav-1 may be the indicators of the progress of formation of hypertrophic scar.

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Egr-1、Nab2、Cav-1的表达及其与瘢痕增生的关系。

目的探讨早期生长反应蛋白1 (Egr-1)、NGFI-A结合蛋白2 (Nab2)和小窝蛋白1 (Cav-1)在正常皮肤、扁平瘢痕和增生性瘢痕中的表达，并探讨其在增生性瘢痕形成中的作用。方法采用免疫组化SP法检测9例正常皮肤组织、8例扁平瘢痕组织和9例增生性瘢痕组织中Egr-1、Nab2和Cav-1蛋白的表达，并进行统计学分析。结果增生性瘢痕表皮细胞中Egr-1的表达明显高于正常皮肤和瘢痕扁平组织。Egr-1的表达在瘢痕增生过程中升高。Nab2的分布模式与Egr-1不同。Egr-1表达升高，Nab2表达降低。Cav-1在正常皮肤及扁平瘢痕组织中的表达明显高于增生性瘢痕组织。结论Egr-1、Nab2和Cav-1的表达与增生性瘢痕的形成密切相关，Egr-1表达上调，Nab2和Cav-1表达不足可能是增生性瘢痕形成进程的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华整形外科杂志

CiteScore

0.20

自引率

0.00%

发文量

5346