Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution.

IF 1.6 Q4 ONCOLOGY

International Journal of Surgical Oncology Pub Date : 2018-05-16 eCollection Date: 2018-01-01 DOI:10.1155/2018/8928706

Francesco Muratori, Leonardo Bettini, Filippo Frenos, Nicola Mondanelli, Daniela Greto, Lorenzo Livi, Alessandro Franchi, Giuliana Roselli, Maurizio Scorianz, Rodolfo Capanna, Domenico Campanacci

{"title":"Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution.","authors":"Francesco Muratori, Leonardo Bettini, Filippo Frenos, Nicola Mondanelli, Daniela Greto, Lorenzo Livi, Alessandro Franchi, Giuliana Roselli, Maurizio Scorianz, Rodolfo Capanna, Domenico Campanacci","doi":"10.1155/2018/8928706","DOIUrl":null,"url":null,"abstract":"Objectives: The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.Methods: 148 MLs were analyzed. The sites of metastases were investigated.Results: Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.Conclusion: Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":"2018 ","pages":"8928706"},"PeriodicalIF":1.6000,"publicationDate":"2018-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011058/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2018/8928706","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.

Methods: 148 MLs were analyzed. The sites of metastases were investigated.

Results: Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.

Conclusion: Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

Abstract Image

查看原文本刊更多论文

肌样脂肪肉瘤：一个机构治疗的 148 例患者的预后因素和转移模式。

研究目的作者报告了一项关于肌样脂肪肉瘤（MLs）的回顾性研究，评估了可能影响总生存期（OS）、无局部复发生存期（LRFS）、无转移生存期（MFS）的因素，并分析了转移模式。方法：对 148 例 ML 进行分析，调查转移部位：边缘（p = 0.002）、分级（p = 0.0479）和转移（p < 0.0001）是影响总生存期（OS）的重要风险因素。发病类型（p = 0.0243）、分级（p = 0.0055）、边缘（p = 0.0001）和局部复发（0.0437）是影响无转移生存期（MFS）的风险因素。作者没有观察到对无局部复发生存期（LRFS）有统计学意义的风险因素，并报告了55%的肺外转移和45%的肺转移：结论：边缘、分级、表现、局部复发和转移是预后因素。肺外转移在肌样脂肪肉瘤中更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Surgical Oncology ONCOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.