TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW.

Q1 Medicine

Current Pathobiology Reports Pub Date : 2018-03-01 Epub Date: 2018-02-04 DOI:10.1007/s40139-018-0161-2

Ricardo Londono, Aaron X Sun, Rocky S Tuan, Thomas P Lozito

{"title":"TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW.","authors":"Ricardo Londono, Aaron X Sun, Rocky S Tuan, Thomas P Lozito","doi":"10.1007/s40139-018-0161-2","DOIUrl":null,"url":null,"abstract":"Purpose of the review: This manuscript discusses wound healing as a component of epimorphic regeneration and the role of the immune system in this process.Recent findings: Epimorphic regeneration involves formation of a blastema, a mass of undifferentiated cells capable of giving rise to the regenerated tissues. The apical epithelial cap plays an important role in blastemal formation.Summary: True regeneration is rarely observed in mammals. With the exception of transgenic strains, tissue repair in mammals usually leads to non-functional fibrotic tissue formation. In contrast, a number of lower order species including planarians, salamanders, and reptiles, have the ability to overcome the burden of scarring and tissue loss through complex adaptations that allow them to regenerate various anatomic structures through epimorphic regeneration. Blastemal cells have been suggested to originate via various mechanisms including de-differentiation, transdifferentiation, migration of pre-existing adult stem cell niches, and combinations of these.","PeriodicalId":37014,"journal":{"name":"Current Pathobiology Reports","volume":" ","pages":"61-69"},"PeriodicalIF":0.0000,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025457/pdf/nihms940053.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Pathobiology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40139-018-0161-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/2/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of the review: This manuscript discusses wound healing as a component of epimorphic regeneration and the role of the immune system in this process.

Recent findings: Epimorphic regeneration involves formation of a blastema, a mass of undifferentiated cells capable of giving rise to the regenerated tissues. The apical epithelial cap plays an important role in blastemal formation.

Summary: True regeneration is rarely observed in mammals. With the exception of transgenic strains, tissue repair in mammals usually leads to non-functional fibrotic tissue formation. In contrast, a number of lower order species including planarians, salamanders, and reptiles, have the ability to overcome the burden of scarring and tissue loss through complex adaptations that allow them to regenerate various anatomic structures through epimorphic regeneration. Blastemal cells have been suggested to originate via various mechanisms including de-differentiation, transdifferentiation, migration of pre-existing adult stem cell niches, and combinations of these.

Abstract Image

查看原文本刊更多论文

组织修复和表皮再生：概述。

综述的目的：本手稿讨论了作为表皮再生组成部分的伤口愈合以及免疫系统在这一过程中的作用：上皮再生涉及胚泡的形成，胚泡是能够产生再生组织的大量未分化细胞。顶端上皮帽在胚泡形成过程中发挥着重要作用。除转基因品系外，哺乳动物的组织修复通常会导致无功能的纤维组织形成。与此相反，包括扁形动物、蝾螈和爬行动物在内的一些低阶物种却有能力通过复杂的适应性克服疤痕和组织缺失带来的负担，使它们能够通过表皮再生技术再生出各种解剖结构。有观点认为，爆破细胞的起源有多种机制，包括去分化、转分化、原有成体干细胞龛位的迁移以及这些机制的组合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.