[Research Progress in Enveloped Glycoproteins and the Membrane-fusion Mechanism of Nipah Virus].

Abstract

Nipah virus (NiV) is the pathogen of an emerging zoonotic disease that is highly lethal and infectious. NiV seriously impacts human lives and the property in the epidemic areas and poses a great threat to the global public health security. This paper provides a brief introduction to the morphological structure, and physiological function of the attachment protein G and the fusion protein F, which are both crucial glycoproteins located on the surface of the virus envelope. Moreover, recent advances in domestic and international research are reviewed. We will consider tissue tropism to elaborate the interactive mechanism between the attachment protein and its protein receptors ephrin-B2/B3,as well as the interactions between the two glycoproteins in detail. Avenues of future research are also discussed.