Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain.

Q1 Medicine

Current Pathobiology Reports Pub Date : 2018-01-01 Epub Date: 2018-01-16 DOI:10.1007/s40139-018-0158-x

Caghan Kizil

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引用次数: 19

Abstract

Purpose of the review: The purpose of this study is to review the current knowledge on the damage-induced molecular programs that underlie the regenerative ability in zebrafish brain.

Recent findings: Neural stem cells are the reservoir for new neurons during development and regeneration of the vertebrate brains. Pathological conditions such as neurodegenerative diseases hamper neural stem cell plasticity and neurogenic outcome in humans, whereas adult zebrafish brain can enhance proliferation and neurogenic capacity of its neural stem cells despite the incipient pathology. Evidence suggests that zebrafish uses damage-induced molecular programs to enable neural stem cells to efficiently initiate regeneration. Since this aptitude may be harnessed for regenerative therapies in human brain, understanding the molecular programs regulating neural stem cell proliferation and quiescence in zebrafish is of utmost importance for clinical efforts.

Summary: Specific molecular programs that are different than those in the homeostatic conditions regulate adult zebrafish neural stem cell plasticity and the regenerative capacity after injury and neurodegeneration. These programs can serve as candidates for stem cell-based regenerative therapies in humans.

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病理诱导的成年斑马鱼大脑神经干细胞可塑性和神经再生机制。

综述的目的:本研究的目的是回顾目前关于斑马鱼大脑再生能力的损伤诱导分子程序的知识。最新研究发现:神经干细胞是脊椎动物大脑发育和再生过程中新神经元的储存库。神经退行性疾病等病理条件阻碍了人类神经干细胞的可塑性和神经原性结果，而成年斑马鱼的大脑可以增强其神经干细胞的增殖和神经原性能力，尽管早期病理。有证据表明，斑马鱼利用损伤诱导的分子程序使神经干细胞有效地启动再生。由于这种能力可以用于人类大脑的再生治疗，因此了解斑马鱼调节神经干细胞增殖和静止的分子程序对临床工作至关重要。摘要:成年斑马鱼神经干细胞在损伤和神经退行性变后的可塑性和再生能力受到不同于稳态条件下的特定分子程序的调控。这些程序可以作为人类干细胞再生疗法的候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Pathobiology Reports Medicine-Pathology and Forensic Medicine

CiteScore

6.40

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most important recent research pertaining to biological mechanisms underlying disease, including etiology, pathogenesis, and the clinical manifestations of cellular alteration. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of new techniques and technologies related to pathobiology is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include autophagy, cancer stem cells, induced pluripotential stem cells (iPS cells), inflammation and cancer, matrix pathobiology, miRNA in pathobiology, mitochondrial dysfunction/diseases, and myofibroblast.